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- 抗原 See all PRKACA 抗体
- PRKACA (Protein Kinase A, alpha (PRKACA))
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抗原表位
- N-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PRKACA antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 交叉反应
- 人, 小鼠, 大鼠
- 纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 免疫原
- Synthesized peptide derived from N-terminal of Human KAPC A/B.
- 亚型
- IgG
- Top Product
- Discover our top product PRKACA Primary Antibody
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anti-Protein Kinase A, alpha (PRKACA) (Center) antibody
PRKACA 适用: 人, 小鼠 WB, IHC (p), IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase A, alpha (PRKACA) (AA 233-351), (Catalytic Subunit alpha) antibodyPRKACA 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase A, alpha (PRKACA) (Internal Region) antibodyPRKACA 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase A, alpha (PRKACA) (pThr197) antibodyPRKACA 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase A, alpha (PRKACA) (AA 1-120) antibodyPRKACA 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 1D7 unconjugated
anti-Protein Kinase A, alpha (PRKACA) (AA 1-120) antibodyPRKACA 适用: 人 ELISA 宿主: 小鼠 Monoclonal 7H3A4 unconjugated
anti-Protein Kinase A, alpha (PRKACA) (AA 1-120) antibodyPRKACA 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Protein Kinase A, alpha (PRKACA) (pSer339) antibodyPRKACA 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase A, alpha (PRKACA) (AA 67-94), (N-Term) antibodyPRKACA 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB20762 unconjugated
anti-Protein Kinase A, alpha (PRKACA) antibodyPRKACA 适用: 人 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB:1:500-1:3000,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- PRKACA (Protein Kinase A, alpha (PRKACA))
- 别名
- PRKACA (PRKACA 产品)
- 别名
- PKACA antibody, Calpha antibody, Cs-PKA antibody, PKCA1 antibody, PKA antibody, PKCD antibody, Pkaca antibody, zgc:158799 antibody, protein kinase cAMP-activated catalytic subunit alpha antibody, protein kinase, cAMP dependent, catalytic, alpha antibody, cAMP-dependent protein kinase catalytic subunit antibody, protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a antibody, PRKACA antibody, Prkaca antibody, kin-1 antibody, prkacaa antibody
- 背景
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Background: Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the regulation of platelets in response to thrombin and collagen, maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP. Prevents the antiproliferative and anti-invasive effects of alpha-difluoromethylornithine in breast cancer cells when activated. RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca2+, leading to reduced amplitude and increased frequency of store overload-induced Ca2+ release (SOICR) characterized by an increased rate of Ca2+ release and propagation velocity of spontaneous Ca2+ waves, despite reduced wave amplitude and resting cytosolic Ca2+. PSMC5/RPT6 activation by phosphorylation stimulates proteasome. Negatively regulates tight junctions (TJs) in ovarian cancer cells via CLDN3 phosphorylation. NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding. Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis. Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation. May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT). Phosphorylates APOBEC3G and AICDA. Isoform 2 phosphorylates and activates ABL1 in sperm flagellum to promote spermatozoa capacitation.
Maldonado F., Nucleic Acids Res. 16:8189-8190(1988).
Desseyn J.-L., Proc. Natl. Acad. Sci. U.S.A. 97:6433-6438(2000).
Ficarro S., J. Biol. Chem. 278:11579-11589(2003).Aliases: cAMP dependent protein kinase alpha catalytic subunit antibody, cAMP dependent protein kinase beta catalytic subunit antibody, cAMP dependent protein kinase catalytic beta subunit isoform 4ab antibody, cAMP dependent protein kinase catalytic subunit alpha antibody, cAMP dependent protein kinase catalytic subunit alpha, isoform 1 antibody, cAMP dependent protein kinase catalytic subunit beta antibody, cAMP-dependent protein kinase catalytic subunit alpha antibody, KAPCA_HUMAN antibody, PKA C alpha antibody, PKA C beta antibody, PKA C-alpha antibody, PKACA antibody, PKACB antibody, PPNAD4 antibody, PRKACA antibody, PRKACAA antibody, PRKACB antibody, Protein kinase A catalytic subunit alpha antibody, Protein kinase A catalytic subunit antibody, Protein kinase A catalytic subunit beta antibody, Protein kinase, cAMP dependent, catalytic, alpha antibody, Protein kinase, cAMP dependent, catalytic, beta antibody
- UniProt
- P17612
- 途径
- NF-kappaB Signaling, Hedgehog Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Carbohydrate Homeostasis, Myometrial Relaxation and Contraction, M Phase, G-protein mediated Events, Signaling Events mediated by VEGFR1 and VEGFR2, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, VEGFR1 Specific Signals, Lipid Metabolism, SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection
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