TRIM24 抗体 (C-Term)
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- 抗原 See all TRIM24 抗体
- TRIM24 (Tripartite Motif Containing 24 (TRIM24))
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抗原表位
- C-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This TRIM24 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 交叉反应
- 人, 小鼠
- 纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 免疫原
- Synthesized peptide derived from C-terminal of Human TRIM24.
- 亚型
- IgG
- Top Product
- Discover our top product TRIM24 Primary Antibody
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- 应用备注
- WB:1:500-1:3000, IHC:1:50-1:100,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- TRIM24 (Tripartite Motif Containing 24 (TRIM24))
- 别名
- TRIM24 (TRIM24 产品)
- 别名
- TRIM24 antibody, PTC6 antibody, RNF82 antibody, TF1A antibody, TIF1 antibody, TIF1A antibody, TIF1ALPHA antibody, hTIF1 antibody, ptc6 antibody, rnf82 antibody, tf1a antibody, tif1 antibody, tif1a antibody, tif1alpha antibody, A130082H20Rik antibody, AI447469 antibody, D430004I05Rik antibody, TIF1-alpha antibody, TIF1alpha antibody, Tif1a antibody, tripartite motif containing 24 antibody, transcription intermediary factor 1-alpha antibody, tripartite motif containing 24 S homeolog antibody, tripartite motif-containing 24 antibody, TRIM24 antibody, trim24 antibody, LOC100548578 antibody, trim24.S antibody, Trim24 antibody
- 背景
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Background: Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes By similarity.
Thenot S., J. Biol. Chem. 272:12062-12068(1997).
Venturini L., Oncogene 18:1209-1217(1999).
Hellal-Levy C., Mol. Endocrinol. 14:1210-1221(2000).Aliases: E3 ubiquitin protein ligase TRIM24 antibody, E3 ubiquitin-protein ligase Trim24 antibody, hTIF1 antibody, PTC6 antibody, RING finger protein 82 antibody, RNF82 antibody, TF1A antibody, TIF1 alpha antibody, TIF1 antibody, TIF1-alpha antibody, TIF1A antibody, TIF1A_HUMAN antibody, TIF1ALPHA antibody, Transcription intermediary factor 1-alpha antibody, Transcriptional intermediary factor 1 alpha antibody, Transcriptional intermediary factor 1 antibody, Trim24 antibody, Tripartite motif containing 24 antibody, Tripartite motif-containing protein 24 antibody
- UniProt
- O15164
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