PAK7 抗体 (C-Term)
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- 抗原 See all PAK7 抗体
- PAK7 (P21 Protein (Cdc42/Rac)-Activated Kinase 7 (PAK7))
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抗原表位
- C-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PAK7 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA
- 交叉反应
- 人
- 纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 免疫原
- Synthesized peptide derived from C-terminal of Human PAK7.
- 亚型
- IgG
- Top Product
- Discover our top product PAK7 Primary Antibody
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- 应用备注
- WB:1:500-1:3000, IHC:1:50-1:100,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- PAK7 (P21 Protein (Cdc42/Rac)-Activated Kinase 7 (PAK7))
- 别名
- PAK5 (PAK7 产品)
- 别名
- PAK5 antibody, pak5 antibody, 2900083L08Rik antibody, 6430627N20 antibody, Pak5 antibody, PAK-5 antibody, PAK-7 antibody, p21 (RAC1) activated kinase 5 antibody, p21 (RAC1) activated kinase 5 L homeolog antibody, p21 protein (Cdc42/Rac)-activated kinase 7 antibody, p21 (RAC1) activated kinase 7 antibody, PAK5 antibody, pak5.L antibody, Pak7 antibody
- 背景
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Background: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions.
Pandey A., Oncogene 21:3939-3948(2002).
Nagase T., DNA Res. 6:337-345(1999).
Deloukas P., Nature 414:865-871(2001).Aliases: EC 2.7.11.1 antibody, KIAA1264 antibody, MGC26232 antibody, p21 activated kinase 7 antibody, p21 protein (Cdc42/Rac)-activated kinase 7 antibody, p21(CDKN1A) activated kinase 7 antibody, p21-activated kinase 5 antibody, p21-activated kinase 7 antibody, PAK 5 antibody, PAK 7 antibody, PAK-5 antibody, PAK-7 antibody, PAK5 antibody, PAK7 antibody, PAK7_HUMAN antibody, Protein kinase PAK5 antibody, Serine/threonine protein kinase PAK 7 antibody, Serine/threonine-protein kinase PAK 7 antibody
- UniProt
- Q9P286
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