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HDAC3 抗体 (C-Term)

HDAC3 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7180182
发货至: 中国
  • 抗原 See all HDAC3 抗体
    HDAC3 (Histone Deacetylase 3 (HDAC3))
    抗原表位
    • 24
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    C-Term
    适用
    • 116
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    宿主
    • 89
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    克隆类型
    • 92
    • 24
    多克隆
    标记
    • 61
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    This HDAC3 antibody is un-conjugated
    应用范围
    • 94
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    • 27
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    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
    交叉反应
    人, 小鼠, 大鼠
    纯化方法
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    免疫原
    Synthesized peptide derived from C-terminal of Human HDAC3.
    亚型
    IgG
    Top Product
    Discover our top product HDAC3 Primary Antibody
  • 应用备注
    WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500,
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原
    HDAC3 (Histone Deacetylase 3 (HDAC3))
    别名
    HDAC3 (HDAC3 产品)
    别名
    CG2128 antibody, DHDAC3 antibody, DmHDAC3 antibody, Dmel\\CG2128 antibody, Dromel_CG2128_FBtr0078767_hdac3_mORF antibody, HDAC antibody, HDAC3 antibody, Hdac 3 antibody, dHDAC3 antibody, dmHDA402 antibody, hdac3 antibody, HDm antibody, hd3 antibody, RPD3 antibody, XRpd3 antibody, rpd3-2 antibody, HD3 antibody, RPD3-2 antibody, AW537363 antibody, zgc:55927 antibody, Histone deacetylase 3 antibody, histone deacetylase 3 antibody, histone deacetylase 3 S homeolog antibody, HDAC3 antibody, hdac3 antibody, CNL05260 antibody, Hdac3 antibody, hdac3.S antibody
    背景

    Background: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1, increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation.

    Xiaohong Zhang, Genes & Dev., Apr 2005, 19: 827 - 839.
    Zhanguo Gao, J. Biol. Chem., Feb 2006, 281: 4540 - 4547. Andrew J. Wilson, J. Biol. Chem., May 2006, 281: 13548 - 13558.

    Aliases: HD3 antibody, HDAC 3 antibody, HDAC3 antibody, HDAC3_HUMAN antibody, Histone deacetylase 3 antibody, RPD3 2 antibody, RPD3 antibody, RPD3-2 antibody, SMAP45 antibody

    UniProt
    O15379
    途径
    Neurotrophin Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
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