FADD 抗体 (C-Term)
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- 抗原 See all FADD 抗体
- FADD (Fas (TNFRSF6)-Associated Via Death Domain (FADD))
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抗原表位
- C-Term
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适用
- 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This FADD antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 交叉反应
- 人, 小鼠
- 纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 免疫原
- Synthesized peptide derived from C-terminal of Human FADD.
- 亚型
- IgG
- Top Product
- Discover our top product FADD Primary Antibody
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- 应用备注
- WB:1:500-1:3000,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- FADD (Fas (TNFRSF6)-Associated Via Death Domain (FADD))
- 别名
- Fadd/FADD (FADD 产品)
- 别名
- MORT1 antibody, Mort1/FADD antibody, Mort1 antibody, TNFRSF6 antibody, adaptor antibody, fadd antibody, mort1 antibody, xfadd antibody, Fas associated via death domain antibody, Fas (TNFRSF6)-associated via death domain antibody, Fas associated via death domain S homeolog antibody, Fas (tnfrsf6)-associated via death domain antibody, FADD antibody, Fadd antibody, fadd.S antibody, fadd antibody
- 背景
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Background: Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis By similarity. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling By similarity.
Zhang J., Mol. Cell. Biol. 16:2756-2763(1996).
Hsu H., Cell 84:299-308(1996).
Carninci P., Science 309:1559-1563(2005)Aliases: Fadd antibody, Mort1FAS-associated death domain protein antibody, FAS-associating death domain-containing protein antibody, Mediator of receptor induced toxicity antibody, Protein FADD antibody
- UniProt
- Q61160
- 途径
- Apoptosis, TLR signaling, Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades
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