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- 抗原 See all PKC gamma (PRKCG) 抗体
- PKC gamma (PRKCG) (Protein Kinase C, gamma (PRKCG))
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抗原表位
- Thr655
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PKC gamma antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 交叉反应
- 人, 小鼠
- 纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 免疫原
- Synthesized non-phosphopeptide derived from Human PRKCG around the phosphorylation site of threonine 655 (A-L-T(p)-P-P).
- 亚型
- IgG
- Top Product
- Discover our top product PRKCG Primary Antibody
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anti-Protein Kinase C, gamma (PRKCG) (pThr514) antibody
PRKCG 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase C, gamma (PRKCG) (AA 260-351) antibodyPRKCG 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Protein Kinase C, gamma (PRKCG) (AA 150-250) antibody (PerCP)PRKCG 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal PerCP
anti-Protein Kinase C, gamma (PRKCG) (AA 150-250) antibody (Atto 488)PRKCG 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal Atto 488
anti-Protein Kinase C, gamma (PRKCG) (AA 150-250) antibody (Atto 594)PRKCG 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal Atto 594
anti-Protein Kinase C, gamma (PRKCG) (AA 150-250) antibody (Atto 390)PRKCG 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal Atto 390
anti-Protein Kinase C, gamma (PRKCG) antibodyPRKCG 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase C, gamma (PRKCG) (Internal Region) antibodyPRKCG 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase C, gamma (PRKCG) (AA 150-250) antibodyPRKCG 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase C, gamma (PRKCG) (AA 150-250) antibody (HRP)PRKCG 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal HRP
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- 应用备注
- WB:1:500-1:3000,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- PKC gamma (PRKCG) (Protein Kinase C, gamma (PRKCG))
- 别名
- PRKCG (PRKCG 产品)
- 别名
- PRKCG antibody, PKC-gamma antibody, PKCC antibody, PKCG antibody, SCA14 antibody, PKCgamma antibody, Pkcc antibody, Prkcc antibody, PKC antibody, PKCI antibody, Prkc antibody, RATPKCI antibody, protein kinase C gamma antibody, protein kinase C, gamma antibody, protein kinase C gamma type antibody, PRKCG antibody, Prkcg antibody, LOC484316 antibody
- 背景
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Background: Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress By similarity. Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage.
Soltoff S.P., Cell 121:271-280(2005).
Comb M.J., Cell 131:1190-1203(2007).
Mann M., Mol. Cell 31:438-448(2008)Aliases: KPCG_HUMAN antibody, MGC57564 antibody, OTTHUMP00000067291 antibody, PKC-gamma antibody, PKCC antibody, PKCG antibody, PRKCG antibody, Protein kinase C gamma antibody, Protein kinase C gamma polypeptide antibody, Protein kinase C gamma type antibody, Protein kinase C, gamma antibody, SCA 14 antibody, SCA14 antibody
- UniProt
- P05129
- 途径
- WNT signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, G-protein mediated Events, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, VEGF Signaling
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