MAPKAP Kinase 2 抗体 (Ser272)
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- 抗原 See all MAPKAP Kinase 2 (MAPKAPK2) 抗体
- MAPKAP Kinase 2 (MAPKAPK2) (Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2))
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抗原表位
- Ser272
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This MAPKAP Kinase 2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA
- 交叉反应
- 人, 小鼠
- 纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 免疫原
- Synthesized non-phosphopeptide derived from Human MAPKAPK2 around the phosphorylation site of serine 272 (A-I-S(p)-P-G).
- 亚型
- IgG
- Top Product
- Discover our top product MAPKAPK2 Primary Antibody
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anti-Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2) (AA 139-367) antibody
MAPKAPK2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2) (AA 302-400) antibodyMAPKAPK2 适用: 人 WB, ELISA, IHC (p), IP, IF, PLA 宿主: 小鼠 Monoclonal 2B3 unconjugated
anti-Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2) (AA 266-352) antibodyMAPKAPK2 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3B8 unconjugated
anti-Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2) (Internal Region) antibodyVerified MAPKAPK2 适用: 人, 小鼠 WB, IHC, ELISA, IP 宿主: 山羊 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2) (AA 301-400) antibodyMAPKAPK2 适用: 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), FACS, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2) (pThr222) antibodyMAPKAPK2 适用: 小鼠, 大鼠, 猴 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2) (pThr334) antibodyMAPKAPK2 适用: 人, 小鼠, 大鼠 IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2) antibodyMAPKAPK2 适用: 人 WB, IHC, ELISA 宿主: 兔 Monoclonal 4H8 unconjugated Recombinant Antibody
anti-Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2) (pThr334) antibodyMAPKAPK2 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2) (pThr334) antibodyMAPKAPK2 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB:1:500-1:3000, IHC:1:50-1:100,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- MAPKAP Kinase 2 (MAPKAPK2) (Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2))
- 别名
- MAPKAPK2 (MAPKAPK2 产品)
- 别名
- mapkapk2 antibody, wu:fb30e10 antibody, wu:fc56c10 antibody, wu:fi03a01 antibody, MGC78852 antibody, MAPKAPK2 antibody, AA960234 antibody, MAPKAP-K2 antibody, MK-2 antibody, MK2 antibody, Rps6kc1 antibody, mitogen-activated protein kinase-activated protein kinase 2a antibody, mitogen-activated protein kinase-activated protein kinase 2 L homeolog antibody, mitogen-activated protein kinase-activated protein kinase 2 antibody, MAP kinase-activated protein kinase 2 antibody, mapkapk2a antibody, mapkapk2.L antibody, MAPKAPK2 antibody, Mapkapk2 antibody
- 背景
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Background: Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, ELAVL1, HNRNPA0, HSF1, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins ELAVL1, HNRNPA0, PABPC1 and TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and phosphorylates HNRNPA0 and PARN, leading to stabilize GADD45A mRNA. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3.
Zu Y.-L., Biochem. Biophys. Res. Commun. 200-1118-1124(1994).
Stokoe D., Biochem. J. 296:843-849(1993).
Coxon P.Y., Cell. Signal. 15:993-1001(2003).Aliases: MAP kinase activated protein Kinase 2 antibody, MAP kinase-activated protein kinase 2 antibody, MAPK activated protein kinase 2 antibody, MAPK-activated protein kinase 2 antibody, MAPK2_HUMAN antibody, MAPKAP K2 antibody, MAPKAP kinase 2 antibody, MAPKAPK 2 antibody, MAPKAPK-2 antibody, MAPKAPK2 antibody, Mitogen activated protein kinase activated protein kinase 2 antibody, MK 2 antibody, MK2 antibody
- UniProt
- P49137
- 途径
- MAPK Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades
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