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- 抗原 See all FYN 抗体
- FYN (FYN Oncogene Related To SRC, FGR, YES (FYN))
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抗原表位
- Tyr530
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This FYN antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 交叉反应
- 人, 小鼠
- 纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 免疫原
- Synthesized non-phosphopeptide derived from Human Fyn around the phosphorylation site of tyrosine 530 (P-Q-Y(p)-Q-P).
- 亚型
- IgG
- Top Product
- Discover our top product FYN Primary Antibody
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anti-FYN Oncogene Related To SRC, FGR, YES (FYN) (AA 7-176) antibody
FYN 适用: 人, 小鼠 WB, IHC (p), IP, ICC 宿主: 小鼠 Monoclonal FYN-01 unconjugated
anti-FYN Oncogene Related To SRC, FGR, YES (FYN) antibodyFYN 适用: 人 ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 2A10 unconjugated
anti-FYN Oncogene Related To SRC, FGR, YES (FYN) (pTyr530) antibodyFYN 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-FYN Oncogene Related To SRC, FGR, YES (FYN) (AA 13-43) antibodyFYN 适用: 人, 小鼠 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-FYN Oncogene Related To SRC, FGR, YES (FYN) (AA 1-537) antibodyFYN 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-FYN Oncogene Related To SRC, FGR, YES (FYN) (AA 1-30) antibodyFYN 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-FYN Oncogene Related To SRC, FGR, YES (FYN) (pTyr530) antibodyFYN 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-FYN Oncogene Related To SRC, FGR, YES (FYN) (pTyr530) antibodyFYN 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-FYN Oncogene Related To SRC, FGR, YES (FYN) (AA 1-482) antibodyFYN 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 3G11-F9 unconjugated
anti-FYN Oncogene Related To SRC, FGR, YES (FYN) (AA 1-90) antibodyFYN 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3A8 unconjugated
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- 应用备注
- WB:1:500-1:3000,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- FYN (FYN Oncogene Related To SRC, FGR, YES (FYN))
- 别名
- FYN (FYN 产品)
- 别名
- im:6908851 antibody, si:dkey-119m7.5 antibody, zgc:109996 antibody, c-fyn antibody, cfyn-a antibody, SLK antibody, SYN antibody, p59-FYN antibody, PKC antibody, fyn antibody, zgc:86720 antibody, AI448320 antibody, AW552119 antibody, FYN proto-oncogene, Src family tyrosine kinase antibody, FYN proto-oncogene, Src family tyrosine kinase S homeolog antibody, FYN proto-oncogene, Src family tyrosine kinase b antibody, FYN proto-oncogene, Src family tyrosine kinase L homeolog antibody, FYN proto-oncogene, Src family tyrosine kinase a antibody, Fyn proto-oncogene antibody, FYN antibody, fyn.S antibody, fynb antibody, fyn.L antibody, Fyn antibody, fyna antibody
- 背景
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Background: Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1.
Kawakami T., Mol. Cell. Biol. 6:4195-4201(1986).
Semba K., Proc. Natl. Acad. Sci. U.S.A. 83:5459-5463(1986).
Rigley K., J. Immunol. 154:1136-1145(1995)Aliases: C syn protooncogene antibody, Fyn antibody, FYN oncogene related to SRC FGR YES antibody, FYN_HUMAN antibody, OKT3 induced calcium influx regulator antibody, P59 FYN antibody, p59-Fyn antibody, Protein tyrosine kinase fyn antibody, Proto oncogene tyrosine protein kinase fyn antibody, Proto-oncogene c-Fyn antibody, Proto-oncogene Syn antibody, Protooncogene Syn antibody, SLK antibody, Src like kinase antibody, Src yes related novel gene antibody, Src-like kinase antibody, Src/yes related novel antibody, SYN antibody, Tyrosine kinase p59fyn T antibody, Tyrosine kinase p59fyn(T) antibody, Tyrosine-protein kinase Fyn antibody
- UniProt
- P06241
- 途径
- JAK/STAT Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Feeding Behaviour, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Activated T Cell Proliferation, Thromboxane A2 Receptor Signaling
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