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- 抗原 See all RIPK1 抗体
- RIPK1 (Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1))
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抗原表位
- AA 1-656
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适用
- 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This RIPK1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunoprecipitation (IP)
- 交叉反应
- 人, 小鼠
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Mouse Receptor-interacting serine/threonine-protein kinase 1 protein (1-656AA)
- 亚型
- IgG
- Top Product
- Discover our top product RIPK1 Primary Antibody
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anti-Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1) (AA 17-289) antibody
RIPK1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1) (AA 1-179) antibodyRIPK1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1) (AA 133-422) antibodyRIPK1 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 2D6 unconjugated
anti-Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1) (AA 170-440) antibodyRIPK1 适用: 人 WB, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1) (AA 131-277) antibodyRIPK1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3B5B6 unconjugated
anti-Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1) (AA 328-458) antibodyRIPK1 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1) (AA 133-422) antibodyRIPK1 适用: 人, 犬 WB 宿主: 小鼠 Monoclonal 2A8 unconjugated
anti-Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1) (AA 133-422) antibodyRIPK1 适用: 人, 犬 WB 宿主: 小鼠 Monoclonal 1A7 unconjugated
anti-Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1) antibodyRIPK1 适用: 人 WB, IP 宿主: 兔 Monoclonal unconjugated
anti-Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1) (AA 316-671) antibodyRIPK1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Recommended dilution: WB:1:500-1:5000, IP:1:200-1:2000,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- RIPK1 (Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1))
- 别名
- Ripk1 (RIPK1 产品)
- 别名
- RIP antibody, RIP1 antibody, D330015H01Rik antibody, Rinp antibody, Rip1 antibody, rip1 antibody, ripk1 antibody, xRIP1beta antibody, xrip1 antibody, receptor interacting serine/threonine kinase 1 antibody, receptor (TNFRSF)-interacting serine-threonine kinase 1 antibody, receptor interacting serine/threonine kinase 1 L homeolog antibody, RIPK1 antibody, Ripk1 antibody, ripk1.L antibody
- 背景
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Background: Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at \\\'Ser-728\\\' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via \\\'Lys-63\\\'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex (By similarity). Interacts with ARHGEF2 (By similarity).
Aliases: Ripk1 antibody, Rinp antibody, Rip antibody, Receptor-interacting serine/threonine-protein kinase 1 antibody, EC 2.7.11.1 antibody, Cell death protein RIP antibody, Receptor-interacting protein 1 antibody, RIP-1 antibody
- UniProt
- Q60855
- 途径
- NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, TLR signaling, Activation of Innate immune Response, Inositol Metabolic Process, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Negative Regulation of intrinsic apoptotic Signaling, SARS-CoV-2 Protein Interactome, Ubiquitin Proteasome Pathway
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