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- 抗原 See all NLRP3 抗体
- NLRP3 (NLR Family, Pyrin Domain Containing 3 (NLRP3))
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抗原表位
- AA 1-153
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适用
- 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This NLRP3 antibody is un-conjugated
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应用范围
- ELISA, Immunofluorescence (IF)
- 交叉反应
- 小鼠
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Mouse NACHT, LRR and PYD domains-containing protein 3 protein (1-153AA)
- 亚型
- IgG
- Top Product
- Discover our top product NLRP3 Primary Antibody
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anti-NLR Family, Pyrin Domain Containing 3 (NLRP3) (AA 1-93), (Pyrin Domain) antibody
NLRP3 适用: 人, 小鼠 WB, IHC, IF, IP 宿主: 小鼠 Monoclonal Cryo-2 unconjugated
anti-NLR Family, Pyrin Domain Containing 3 (NLRP3) (AA 15-120) antibodyNLRP3 适用: 人, 小鼠, 大鼠, 犬 WB, ELISA, FACS, IHC (p), IF (p), ICC, IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 3 (NLRP3) (AA 671-1033) antibodyNLRP3 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 3 (NLRP3) (C-Term) antibodyVerified NLRP3 适用: 人 ELISA, IHC, FACS, IF 宿主: 山羊 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 3 (NLRP3) (C-Term) antibodyNLRP3 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 3 (NLRP3) (N-Term) antibodyNLRP3 适用: 人, 小鼠, 大鼠 WB, FACS, IHC (p), IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 3 (NLRP3) (AA 30-102) antibodyNLRP3 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 3 (NLRP3) (AA 1-100) antibodyNLRP3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3B1 unconjugated
anti-NLR Family, Pyrin Domain Containing 3 (NLRP3) (AA 21-194) antibodyNLRP3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 3 (NLRP3) (AA 65-91), (N-Term) antibodyNLRP3 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB22404 unconjugated
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- 应用备注
- Recommended dilution: IF:1:50-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- NLRP3 (NLR Family, Pyrin Domain Containing 3 (NLRP3))
- 别名
- Nlrp3 (NLRP3 产品)
- 别名
- CIAS1 antibody, Nalp3 antibody, avp antibody, cias1 antibody, nalp3 antibody, pypaf1 antibody, agtavprl antibody, AGTAVPRL antibody, AII antibody, AVP antibody, C1orf7 antibody, CLR1.1 antibody, FCAS antibody, FCU antibody, MWS antibody, NALP3 antibody, PYPAF1 antibody, AII/AVP antibody, Cias1 antibody, Mmig1 antibody, Pypaf1 antibody, NLR family pyrin domain containing-like antibody, NLR family pyrin domain containing 3 antibody, NLR family, pyrin domain containing 3 L homeolog antibody, NLR family, pyrin domain containing 3 antibody, NLRPL antibody, NLRP3 antibody, nlrp3.L antibody, Nlrp3 antibody
- 背景
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Background: As the sensor component of the NLRP3 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP3, PYCARD and CASP1 (or possibly CASP4/CASP11). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP3 inflammasome is also required for HMGB1 secretion (PubMed:22801494). The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death. Under resting conditions, NLRP3 is autoinhibited. NLRP3 activation stimuli include extracellular ATP, reactive oxygen species, K(+) efflux, crystals of monosodium urate or cholesterol, beta-amyloid fibers, environmental or industrial particles and nanoparticles, etc. However, it is unclear what constitutes the direct NLRP3 activator. Independently of inflammasome activation, regulates the differentiation of T helper 2 (Th2) cells and has a role in Th2 cell-dependent asthma and tumor growth. During Th2 differentiation, required for optimal IRF4 binding to IL4 promoter and for IRF4-dependent IL4 transcription. Binds to the consensus DNA sequence 5\'-GRRGGNRGAG-3\'. May also participate in the transcription of IL5, IL13, GATA3, CCR3, CCR4 and MAF (PubMed:26098997).
Aliases: Nlrp3 antibody, Cias1 antibody, Mmig1 antibody, Nalp3 antibody, Pypaf1 antibody, NACHT antibody, LRR and PYD domains-containing protein 3 antibody, Cold autoinflammatory syndrome 1 protein homolog antibody, Cryopyrin antibody, Mast cell maturation-associated-inducible protein 1 antibody, PYRIN-containing APAF1-like protein 1 antibody
- UniProt
- Q8R4B8
- 途径
- Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Inflammasome
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