EGLN3 抗体 (AA 2-239) (Biotin)
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- 抗原 See all EGLN3 抗体
- EGLN3 (Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))
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抗原表位
- AA 2-239
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适用
- 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This EGLN3 antibody is conjugated to Biotin
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应用范围
- ELISA
- 交叉反应
- 小鼠
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Mouse Egl nine homolog 3 protein (2-239AA)
- 亚型
- IgG
- Top Product
- Discover our top product EGLN3 Primary Antibody
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anti-Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3) (AA 1-120) antibody
EGLN3 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3) (AA 1-239) antibodyEGLN3 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3) (AA 1-120) antibodyEGLN3 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3) (AA 2-239) antibodyEGLN3 适用: 小鼠 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3) antibodyEGLN3 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3) (AA 1-239) antibodyEGLN3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3) (AA 94-193) antibodyEGLN3 适用: 人 ELISA 宿主: 小鼠 Monoclonal 3C5 unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3) (Internal Region) antibodyVerified EGLN3 适用: 人 ELISA, WB 宿主: 山羊 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3) (AA 50-100) antibodyEGLN3 适用: 人, 大鼠, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3) (C-Term) antibodyEGLN3 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, Pig, 兔, 猴, 豚鼠, 小鸡 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- EGLN3 (Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))
- 别名
- Egln3 (EGLN3 产品)
- 别名
- zgc:77019 antibody, wu:fj78a08 antibody, EGLN3 antibody, phd3 antibody, PHD-3 antibody, PHD3 antibody, SM-20 antibody, 2610021G09Rik antibody, AI505553 antibody, AI648162 antibody, Hif-p4h-3 antibody, Phd3 antibody, HIFP4H3 antibody, HIFPH3 antibody, egl-9 family hypoxia-inducible factor 3 antibody, egl-9 family hypoxia inducible factor 3 antibody, egl-9 family hypoxia-inducible factor 3 L homeolog antibody, egln3 antibody, EGLN3 antibody, egln3.L antibody, Egln3 antibody
- 背景
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Background: Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylation on the NODD site by EGLN3 appears to require prior hydroxylation on the CODD site. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. ELGN3 is the most important isozyme in limiting physiological activation of HIFs (particularly HIF2A) in hypoxia. Also hydroxylates PKM in hypoxia, limiting glycolysis. Under normoxia, hydroxylates and regulates the stability of ADRB2. Regulator of cardiomyocyte and neuronal apoptosis. In cardiomyocytes, inhibits the anti-apoptotic effect of BCL2 by disrupting the BAX-BCL2 complex. In neurons, has a NGF-induced proapoptotic effect, probably through regulating CASP3 activity. Also essential for hypoxic regulation of neutrophilic inflammation.
Aliases: Egln3Egl nine homolog 3 antibody, EC 1.14.11.29 antibody, Hypoxia-inducible factor prolyl hydroxylase 3 antibody, HIF-PH3 antibody, HIF-prolyl hydroxylase 3 antibody, HPH-3 antibody, Prolyl hydroxylase domain-containing protein 3 antibody, PHD3 antibody, SM-20 antibody
- UniProt
- Q91UZ4
- 途径
- Positive Regulation of Endopeptidase Activity
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