RPA2 抗体 (pThr21)
Quick Overview for RPA2 抗体 (pThr21) (ABIN713351)
抗原
See all RPA2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pThr21
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交叉反应
- 小鼠, 大鼠
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预测反应
- Human,Dog,Cow,Pig,Chicken
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic phosphopeptide derived from human RPA2 around the phosphorylation site of Thr21
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亚型
- IgG
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anti-Replication Protein A2, 32kDa (RPA2) (AA 1-270) antibody
RPA2 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Polyclonal unconjugated
anti-Replication Protein A2, 32kDa (RPA2) antibodyRPA2 适用: 人, 犬, 猴 WB, IHC, IF, IHC (p), IP, FACS 宿主: 小鼠 Monoclonal 7C12 unconjugated
anti-Replication Protein A2, 32kDa (RPA2) antibodyRPA2 适用: 人, 大鼠, 犬, 猴 WB, IHC, IF, IHC (p), IP, FACS 宿主: 小鼠 Monoclonal 1H10 unconjugated
anti-Replication Protein A2, 32kDa (RPA2) antibodyRPA2 适用: 人, 猴 WB, IHC, IF, IHC (p), IP, FACS 宿主: 小鼠 Monoclonal 9A1 unconjugated
anti-Replication Protein A2, 32kDa (RPA2) (AA 1-267) antibodyRPA2 适用: 人 WB, ELISA, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Replication Protein A2, 32kDa (RPA2) antibodyRPA2 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Replication Protein A2, 32kDa (RPA2) (N-Term) antibodyRPA2 适用: 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Replication Protein A2, 32kDa (RPA2) (pThr21) antibodyRPA2 适用: 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Replication Protein A2, 32kDa (RPA2) (AA 101-200) antibodyRPA2 适用: 小鼠 WB, ELISA, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Replication Protein A2, 32kDa (RPA2) (pSer33) antibodyRPA2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- RPA2 (Replication Protein A2, 32kDa (RPA2))
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别名
- RPA2
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背景
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Synonyms: REPA2, RPA32, RP-A p32, RP-A p34, Replication protein A 32 kDa subunit, Replication factor A protein 2, RF-A protein 2, Replication protein A 34 kDa subunit, RPA2, RPA34
Background: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Through RFWD3 may activate CHEK1 and play a role in replication checkpoint control. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance.
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基因ID
- 6118
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UniProt
- P15927
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途径
- Telomere Maintenance, DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA
抗原
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