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RAD23B 抗体 (AA 1-250)

RAD23B 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7175174
发货至: 中国
  • 抗原 See all RAD23B 抗体
    RAD23B (RAD23 Homolog B (RAD23B))
    抗原表位
    • 15
    • 13
    • 7
    • 6
    • 6
    • 4
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-250
    适用
    • 87
    • 37
    • 36
    • 6
    • 6
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    宿主
    • 68
    • 18
    • 1
    克隆类型
    • 70
    • 17
    多克隆
    标记
    • 47
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This RAD23B antibody is un-conjugated
    应用范围
    • 67
    • 28
    • 24
    • 15
    • 15
    • 14
    • 13
    • 10
    • 8
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    交叉反应
    纯化方法
    >95%, Protein G purified
    免疫原
    Recombinant Human UV excision repair protein RAD23 homolog B protein (1-250AA)
    亚型
    IgG
    Top Product
    Discover our top product RAD23B Primary Antibody
  • 应用备注
    Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200,
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原
    RAD23B (RAD23 Homolog B (RAD23B))
    别名
    RAD23B (RAD23B 产品)
    别名
    HHR23B antibody, HR23B antibody, P58 antibody, 0610007D13Rik antibody, AV001138 antibody, mHR23B antibody, p58 antibody, MGC107846 antibody, zgc:65951 antibody, RAD23 homolog B, nucleotide excision repair protein antibody, UV excision repair protein RAD23 homolog B antibody, RAD23 homolog B, nucleotide excision repair protein S homeolog antibody, RAD23B antibody, Rad23b antibody, rd23b antibody, rad23b antibody, rad23b.S antibody
    背景

    Background: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome. Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with CETN2 appears to stabilize XPC. May protect XPC from proteasomal degradation. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5\\\'-to-3\\\' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER, it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts. XPC:RAD23B contacts DNA both 5\\\' and 3\\\' of a cisplatin lesion with a preference for the 5\\\' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1.

    Aliases: hHR 23b antibody, hHR23B antibody, HR 23B antibody, HR23B antibody, mHR 23B antibody, mHR23B antibody, p58 antibody, RAD 23B antibody, RAD23 (S. cerevisiae) homolog B antibody, RAD23 homolog B (S. cerevisiae) antibody, RAD23 homolog B antibody, RAD23 yeast homolog of B antibody, Rad23b antibody, RD23B_HUMAN antibody, UV excision repair protein RAD23 homolog B antibody, XP C repair complementing complex 58 kDa antibody, XP C repair complementing complex 58 kDa protein antibody, XP C repair complementing protein antibody, XP-C repair-complementing complex 58 kDa protein antibody, XPC repair complementing complex 58 kDa antibody, XPC repair complementing complex 58 kDa protein antibody, XPC repair complementing protein antibody

    UniProt
    P54727
    途径
    DNA Damage Repair
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