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UBE2N 抗体 (AA 20-138)

UBE2N 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7174472
发货至: 中国
  • 抗原 See all UBE2N 抗体
    UBE2N (Ubiquitin-Conjugating Enzyme E2N (UBE2N))
    抗原表位
    • 15
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    AA 20-138
    适用
    • 37
    • 35
    • 33
    • 6
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    宿主
    • 47
    • 4
    • 1
    克隆类型
    • 40
    • 12
    多克隆
    标记
    • 21
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This UBE2N antibody is un-conjugated
    应用范围
    • 20
    • 15
    • 13
    • 13
    • 5
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
    交叉反应
    纯化方法
    >95%, Protein G purified
    免疫原
    Recombinant Human Ubiquitin-conjugating enzyme E2 N protein (20-138AA)
    亚型
    IgG
    Top Product
    Discover our top product UBE2N Primary Antibody
  • 应用备注
    Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200,
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原
    UBE2N (Ubiquitin-Conjugating Enzyme E2N (UBE2N))
    别名
    UBE2N (UBE2N 产品)
    别名
    UBC13 antibody, UbcH-ben antibody, UbcH13 antibody, 1500026J17Rik antibody, AL022654 antibody, BB101821 antibody, ube2n antibody, wu:fb11b03 antibody, wu:fc08b06 antibody, zgc:55726 antibody, ubc13 antibody, ubch-ben antibody, UBE2N antibody, ube2nl antibody, zgc:63901 antibody, ubiquitin conjugating enzyme E2 N antibody, ubiquitin-conjugating enzyme E2N antibody, ubiquitin conjugating enzyme E2 N S homeolog antibody, ubiquitin-conjugating enzyme E2Na antibody, ubiquitin-conjugating enzyme E2Nb antibody, UBE2N antibody, Ube2n antibody, ube2n.S antibody, ube2na antibody, LOC100533434 antibody, ube2n antibody, ube2nb antibody
    背景

    Background: The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical \\\'Lys-63\\\'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the \\\'Lys-63\\\'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the \\\'Lys-63\\\'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate \\\'Lys-63\\\'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes.

    Aliases: Bendless like ubiquitin conjugating enzyme antibody, Bendless-like ubiquitin-conjugating enzyme antibody, BLU antibody, EC 6.3.2.19 antibody, Epididymis secretory protein Li 71 antibody, HEL-S-71 antibody, Human epidermoid carcinoma mRNA for ubiquitin-conjugating enzyme E2 similar to Drosophila bendless gene product complete cds antibody, MGC131857 antibody, MGC8489 antibody, UBC 13 antibody, Ubc13 antibody, UbCH ben antibody, UbcH-ben antibody, UbcH13 antibody, UBCHBEN antibody, Ube 2N antibody, Ube2n antibody, UBE2N_HUMAN antibody, Ubiquitin carrier protein N antibody, Ubiquitin conjugating enzyme E2 N antibody, Ubiquitin conjugating enzyme E2N (homologous to yeast UBC13) antibody, Ubiquitin conjugating enzyme E2N (UBC13 homolog yeast) antibody, Ubiquitin conjugating enzyme E2N antibody, Ubiquitin protein ligase N antibody, Ubiquitin-conjugating enzyme E2 N antibody, Ubiquitin-protein ligase N antibody, Yeast UBC13 homolog antibody

    UniProt
    P61088
    途径
    TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, Positive Regulation of Response to DNA Damage Stimulus, Ubiquitin Proteasome Pathway
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