UCHL3 抗体 (C-Term)
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- 抗原 See all UCHL3 (Uchl3) 抗体
- UCHL3 (Uchl3) (Ubiquitin Carboxyl-terminal Esterase L3 (Ubiquitin Thiolesterase) (Uchl3))
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抗原表位
- AA 1-220, C-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This UCHL3 antibody is un-conjugated
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应用范围
- Immunohistochemistry (IHC), ELISA
- 交叉反应
- 人
- 纯化方法
- Antigen Affinity Purified
- 免疫原
- Recombinant Human Ubiquitin carboxyl-terminal hydrolase isozyme L3 protein (1-220AA)
- 亚型
- IgG
- Top Product
- Discover our top product Uchl3 Primary Antibody
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- 应用备注
- Recommended dilution: IHC:1:20-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- UCHL3 (Uchl3) (Ubiquitin Carboxyl-terminal Esterase L3 (Ubiquitin Thiolesterase) (Uchl3))
- 别名
- UCHL3 (Uchl3 产品)
- 别名
- UCH-L3 antibody, UCH-6 antibody, RGD1561196 antibody, im:6908825 antibody, zgc:109963 antibody, uchl4 antibody, ubiquitin C-terminal hydrolase L3 antibody, ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) antibody, ubiquitin C-terminal hydrolase L3 L homeolog antibody, UCHL3 antibody, Uchl3 antibody, uchl3 antibody, uchl3.L antibody
- 背景
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Background: Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3\\\", and exhibits a preference towards \\\'Lys-48\\\'-linked Ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders.
Aliases: Ubiquitin carboxyl-terminal hydrolase isozyme L3 antibody, Ubiquitin thioesterase L3 antibody, Ubiquitin thiolesterase antibody, Ubiquitin thiolesterase L3 antibody, UCH L3 antibody, UCH-L3 antibody, UCHL3 antibody, UCHL3_HUMAN antibody
- UniProt
- P15374
- 途径
- Feeding Behaviour, Positive Regulation of fat Cell Differentiation
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