USP1 抗体 (AA 453-592) (Biotin)
Quick Overview for USP1 抗体 (AA 453-592) (Biotin) (ABIN7174251)
抗原
See all USP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 453-592
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Ubiquitin carboxyl-terminal hydrolase 10 protein (453-592AA)
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亚型
- IgG
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anti-Ubiquitin Specific Peptidase 1 (USP1) (AA 453-592) antibody
USP1 适用: 人 WB, ELISA, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 1 (USP1) (AA 701-785) antibodyUSP1 适用: 人 ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 1 (USP1) (C-Term) antibodyUSP1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 1 (USP1) antibodyUSP1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 1 (USP1) (AA 1-785) antibodyUSP1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 1 (USP1) (AA 701-750) antibodyUSP1 适用: 人, 小鼠, 犬, 马, 豚鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 1 (USP1) (AA 486-785) antibodyUSP1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 1 (USP1) (AA 1-198) antibodyUSP1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 1 (USP1) (AA 607-637), (C-Term) antibodyUSP1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB4199 unconjugated
anti-Ubiquitin Specific Peptidase 1 (USP1) (C-Term) antibodyUSP1 适用: 人, 小鼠, 大鼠, 犬, 马, Cow, Pig, 兔, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- USP1 (Ubiquitin Specific Peptidase 1 (USP1))
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别名
- USP1
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背景
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Background: Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989).
Aliases: Deubiquitinating enzyme 10 antibody, KIAA0190 antibody, MGC124997 antibody, MGC2621 antibody, Ubiquitin carboxyl terminal hydrolase 10 antibody, Ubiquitin carboxyl-terminal hydrolase 10 antibody, Ubiquitin specific peptidase 10 antibody, Ubiquitin specific processing protease 10 antibody, Ubiquitin specific protease 10 antibody, Ubiquitin thioesterase 10 antibody, Ubiquitin thiolesterase 10 antibody, Ubiquitin-specific-processing protease 10 antibody, UBP10_HUMAN antibody, UBPO antibody, USP 10 antibody, USP10 antibody
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UniProt
- Q14694
抗原
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