TP53INP1 抗体 (AA 138-205)
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- 抗原 See all TP53INP1 抗体
- TP53INP1 (Tumor Protein P53 Inducible Nuclear Protein 1 (TP53INP1))
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抗原表位
- AA 138-205
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This TP53INP1 antibody is un-conjugated
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应用范围
- ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- 交叉反应
- 人
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human Tumor protein p53-inducible nuclear protein 1 protein (138-205AA)
- 亚型
- IgG
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- 应用备注
- Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- TP53INP1 (Tumor Protein P53 Inducible Nuclear Protein 1 (TP53INP1))
- 别名
- TP53INP1 (TP53INP1 产品)
- 背景
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Background: Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on \'Ser-46\' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.
Aliases: DKFZp434M1317 antibody, FLJ22139 antibody, p53 damage inducible nuclear protein 1 antibody, p53 dependent damage inducible nuclear protein 1 antibody, p53 inducible nuclear protein 1 antibody, p53 inducible p53DINP1 antibody, p53-dependent damage-inducible nuclear protein 1 antibody, p53DINP1 antibody, SIP antibody, Stress induced protein antibody, Stress-induced protein antibody, T53I1_HUMAN antibody, Teap antibody, TP53 DINP1 antibody, TP53 INP1 antibody, TP53DINP1 antibody, TP53INP1 antibody, TP53INP1A antibody, TP53INP1B antibody, Tumor protein p53 inducible nuclear protein 1 antibody, Tumor protein p53-inducible nuclear protein 1 antibody
- UniProt
- Q96A56
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