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- 抗原 See all TRIM5 抗体
- TRIM5 (Tripartite Motif Containing 5 (TRIM5))
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抗原表位
- AA 1-493
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This TRIM5 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 交叉反应
- 人, 小鼠
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human Tripartite motif-containing protein 5 protein (1-493AA)
- 亚型
- IgG
- Top Product
- Discover our top product TRIM5 Primary Antibody
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anti-Tripartite Motif Containing 5 (TRIM5) (N-Term) antibody
Verified TRIM5 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Tripartite Motif Containing 5 (TRIM5) (N-Term) antibodyTRIM5 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 5 (TRIM5) antibodyTRIM5 适用: 人 WB, ELISA, IHC 宿主: 小鼠 Monoclonal 3B11H2 unconjugated
anti-Tripartite Motif Containing 5 (TRIM5) antibodyTRIM5 适用: 人, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 5 (TRIM5) (C-Term) antibodyTRIM5 适用: 人, 猴 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 5 (TRIM5) antibodyTRIM5 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 5 (TRIM5) (AA 35-84) antibodyTRIM5 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 5 (TRIM5) (AA 100-200) antibodyTRIM5 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 5 (TRIM5) (N-Term) antibodyTRIM5 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 5 (TRIM5) (Middle Region 1) antibodyTRIM5 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- TRIM5 (Tripartite Motif Containing 5 (TRIM5))
- 别名
- TRIM5 (TRIM5 产品)
- 别名
- TRIM5 antibody, RNF88 antibody, TRIM5alpha antibody, EG667823 antibody, Gm8833 antibody, RGD1304579 antibody, tripartite motif containing 5 antibody, tripartite motif-containing 5 antibody, TRIM5 antibody, Trim5 antibody
- 背景
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Background: Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates \\\'Lys-63\\\'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Restricts infection by N-tropic murine leukemia virus (N-MLV), equine infectious anemia virus (EIAV), simian immunodeficiency virus of macaques (SIVmac), feline immunodeficiency virus (FIV), and bovine immunodeficiency virus (BIV) (PubMed:17156811). Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2 (PubMed:25127057). Also plays a role in autophagy by acting as a selective autophagy receptor which recognizes and targets HIV-1 capsid protein p24 for autophagic destruction (PubMed:25127057).
Aliases: RING finger protein 88 antibody, RNF88 antibody, TRIM5 antibody, TRIM5_HUMAN antibody, TRIM5alpha antibody, Tripartite motif containing 5 antibody, tripartite motif protein TRIM5 antibody, Tripartite motif-containing protein 5 antibody
- UniProt
- Q9C035
- 途径
- Activation of Innate immune Response
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