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TLR6 抗体 (AA 32-586)

TLR6 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7172278
发货至: 中国
  • 抗原 See all TLR6 抗体
    TLR6 (Toll-Like Receptor 6 (TLR6))
    抗原表位
    • 8
    • 8
    • 7
    • 4
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    • 2
    • 1
    • 1
    • 1
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    AA 32-586
    适用
    • 61
    • 21
    • 3
    • 3
    • 2
    • 1
    • 1
    宿主
    • 45
    • 18
    • 1
    克隆类型
    • 45
    • 19
    多克隆
    标记
    • 37
    • 8
    • 5
    • 3
    • 3
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    This TLR6 antibody is un-conjugated
    应用范围
    • 36
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    • 7
    • 7
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    • 1
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    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
    交叉反应
    纯化方法
    >95%, Protein G purified
    免疫原
    Recombinant Human Toll-like receptor 6 protein (32-586AA)
    亚型
    IgG
    Top Product
    Discover our top product TLR6 Primary Antibody
  • 应用备注
    Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200, IF:1:50-1:200,
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原
    TLR6 (Toll-Like Receptor 6 (TLR6))
    别名
    TLR6 (TLR6 产品)
    别名
    TLR1 antibody, TLR16 antibody, CD286 antibody, TLR-6 antibody, toll-like receptor 1 family member A antibody, toll like receptor 6 antibody, toll-like receptor 6 antibody, TLR1A antibody, TLR6 antibody, Tlr6 antibody
    背景

    Background: Participates in the innate immune response to bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2 (PubMed:11441107). In complex with TLR4, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.

    Aliases: CD286 antibody, CD286 antigen antibody, TLR 6 antibody, Tlr6 antibody, TLR6_HUMAN antibody, Toll like receptor 6 precursor antibody, Toll-like receptor 6 antibody

    UniProt
    Q9Y2C9
    途径
    TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
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