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TSPAN12 抗体 (AA 111-224) (FITC)

TSPAN12 适用: 人 宿主: 兔 Polyclonal FITC
产品编号 ABIN7171848
发货至: 中国
  • 抗原 See all TSPAN12 抗体
    TSPAN12 (Tetraspanin 12 (TSPAN12))
    抗原表位
    • 15
    • 8
    • 7
    • 4
    • 2
    • 1
    • 1
    AA 111-224
    适用
    • 42
    • 23
    • 8
    • 5
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    宿主
    • 42
    克隆类型
    • 42
    多克隆
    标记
    • 17
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TSPAN12 antibody is conjugated to FITC
    应用范围
    请咨询
    交叉反应
    纯化方法
    >95%, Protein G purified
    免疫原
    Recombinant Human Tetraspanin-12 protein (111-224AA)
    亚型
    IgG
    Top Product
    Discover our top product TSPAN12 Primary Antibody
  • 限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原
    TSPAN12 (Tetraspanin 12 (TSPAN12))
    别名
    TSPAN12 (TSPAN12 产品)
    别名
    tm4sf12 antibody, zgc:63880 antibody, EVR5 antibody, NET-2 antibody, NET2 antibody, TM4SF12 antibody, 9030619E17 antibody, AI426782 antibody, AI663988 antibody, AW111457 antibody, Tm4sf12 antibody, tetraspanin-7 antibody, tetraspanin 12 antibody, LOC412465 antibody, TSPAN12 antibody, tspan12 antibody, Tspan12 antibody
    背景

    Background: Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1) (By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity.

    Aliases: TSPAN12 antibody, NET2 antibody, TM4SF12 antibody, UNQ774/PRO1568Tetraspanin-12 antibody, Tspan-12 antibody, Tetraspan NET-2 antibody, Transmembrane 4 superfamily member 12 antibody

    UniProt
    O95859
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