SRPK2 抗体 (AA 471-688) (HRP)
-
- 抗原 See all SRPK2 抗体
- SRPK2 (SFRS Protein Kinase 2 (SRPK2))
-
抗原表位
- AA 471-688
-
适用
- 人
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This SRPK2 antibody is conjugated to HRP
-
应用范围
- ELISA
- 交叉反应
- 人
- 纯化方法
- Antigen Affinity Purified
- 免疫原
- Recombinant Human SRSF protein kinase 2 protein (471-688AA)
- 亚型
- IgG
- Top Product
- Discover our top product SRPK2 Primary Antibody
-
-
- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 缓冲液
-
Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
- 抗原
- SRPK2 (SFRS Protein Kinase 2 (SRPK2))
- 别名
- SRPK2 (SRPK2 产品)
- 别名
- SFRSK2 antibody, AW226533 antibody, AW492537 antibody, AW547358 antibody, Wbp6 antibody, mSRPK2 antibody, sfrsk2 antibody, srpk2 antibody, srpk2-b antibody, srpk2b antibody, SRSF protein kinase 2 antibody, serine/arginine-rich protein specific kinase 2 antibody, SRSF protein kinase 2 L homeolog antibody, SRPK2 antibody, Srpk2 antibody, srpk2 antibody, srpk2.L antibody
- 背景
-
Background: Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation. Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28. Can mediate hepatitis B virus (HBV) core protein phosphorylation. Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles.
Aliases: Human serine kinase SRPK2 mRNA, complete cds antibody, Serine kinase SRPK2 antibody, Serine/arginine rich protein specific kinase 2 antibody, Serine/arginine-rich protein-specific kinase 2 antibody, Serine/threonine protein kinase SRPK2 antibody, SFRS protein kinase 2 antibody, SFRSK2 antibody, SR protein specific kinase 2 antibody, SR-protein-specific kinase 2 antibody, SRPK2 antibody, SRPK2_HUMAN antibody, SRSF protein kinase 2 C-terminal antibody
- UniProt
- P78362
- 途径
- Ribonucleoprotein Complex Subunit Organization
-