SLAMF6 抗体 (AA 248-331)
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- 抗原 See all SLAMF6 抗体
- SLAMF6 (SLAM Family Member 6 (SLAMF6))
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抗原表位
- AA 248-331
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SLAMF6 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- 交叉反应
- 人, 小鼠
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human SLAM family member 6 protein (248-331AA)
- 亚型
- IgG
- Top Product
- Discover our top product SLAMF6 Primary Antibody
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anti-SLAM Family Member 6 (SLAMF6) (AA 22-226) antibody
SLAMF6 适用: 人 WB, ELISA, FACS, IHC, ICC, Neut 宿主: 小鼠 Monoclonal 2F1C9 unconjugated
anti-SLAM Family Member 6 (SLAMF6) (AA 1-271) antibodySLAMF6 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-SLAM Family Member 6 (SLAMF6) antibodySLAMF6 适用: 人 FACS, ICC, IP 宿主: 小鼠 Monoclonal hsF6-4-20 unconjugated
anti-SLAM Family Member 6 (SLAMF6) antibody (PE)SLAMF6 适用: 人 FACS 宿主: 小鼠 Monoclonal hsF6-4-20 PE
anti-SLAM Family Member 6 (SLAMF6) (AA 51-150) antibodySLAMF6 适用: 小鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-SLAM Family Member 6 (SLAMF6) (Extracellular Domain) antibodySLAMF6 适用: 人 FACS 宿主: 小鼠 Monoclonal NT-7 unconjugated
anti-SLAM Family Member 6 (SLAMF6) antibodySLAMF6 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-SLAM Family Member 6 (SLAMF6) (AA 51-100) antibodySLAMF6 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-SLAM Family Member 6 (SLAMF6) (AA 74-123) antibodySLAMF6 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-SLAM Family Member 6 (SLAMF6) (AA 22-226) antibodySLAMF6 适用: 人 ELISA, FACS 宿主: 兔 Monoclonal DM159 unconjugated
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- 应用备注
- Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500, IF:1:50-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- SLAMF6 (SLAM Family Member 6 (SLAMF6))
- 别名
- SLAMF6 (SLAMF6 产品)
- 别名
- SLAMF6 antibody, CD352 antibody, KALI antibody, KALIb antibody, Ly108 antibody, NTB-A antibody, NTBA antibody, SF2000 antibody, KAL1 antibody, KAL1b antibody, RGD1561848 antibody, SLAM family member 6 antibody, SLAMF6 antibody, Slamf6 antibody
- 背景
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Background: Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors (PubMed:11489943, PubMed:16920955). Positive signaling in NK cells implicates phosphorylation of VAV1. NK cell activation seems to depend on SH2D1B and not on SH2D1A (PubMed:16920955). In conjunction with SLAMF1 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage (By similarity). Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion, the costimulatory activity requires SH2D1A (PubMed:22184727, PubMed:16920955). Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874). In conjunction with SLAMF1 and CD84/SLAMF5 may be a negative regulator of the humoral immune response. In the absence of SH2D1A/SAP can transmit negative signals to CD4(+) T-cells and NKT cells. Negatively regulates germinal center formation by inhibiting T-cell:B-cell adhesion, the function probably implicates increased association with PTPN6/SHP-1 via ITSMs in absence of SH2D1A/SAP. However, reported to be involved in maintaining B-cell tolerance in germinal centers and in preventing autoimmunity (By similarity).
Aliases: Activating NK receptor antibody, CD352 antibody, KALI antibody, KALIb antibody, LY108 antibody, MGC104953 antibody, Natural killer T and B cell antigen antibody, NK T B antigen antibody, NK-, T-, and B-cell antigen antibody, NK-T-B-antigen antibody, NTB A antibody, NTB-A antibody, NTBA antibody, NTBA receptor antibody, SF2000 antibody, SLAF6_HUMAN antibody, SLAM family member 6 antibody, SLAM family member 6 precursor antibody, SLAM Family Receptor antibody, Slamf6 antibody
- UniProt
- Q96DU3
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