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- 抗原 See all SPPL3 抗体
- SPPL3 (Signal Peptide Peptidase 3 (SPPL3))
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抗原表位
- AA 213-263
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SPPL3 antibody is un-conjugated
- 应用范围
- ELISA, Western Blotting (WB), Immunofluorescence (IF)
- 交叉反应
- 人
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human Signal peptide peptidase-like 3 protein (213-263AA)
- 亚型
- IgG
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anti-Signal Peptide Peptidase 3 (SPPL3) (AA 215-264) antibody
SPPL3 适用: 人, 小鸡, Cow, 豚鼠, 马, 猴, 小鼠, Pig, 兔, 大鼠, 非洲爪蟾, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Recommended dilution: WB:1:200-1:2000, IF:1:50-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- SPPL3 (Signal Peptide Peptidase 3 (SPPL3))
- 别名
- SPPL3 (SPPL3 产品)
- 别名
- CG17370 antibody, CG5901 antibody, Dmel\\CG17370 antibody, SPPL3 antibody, Sppl antibody, sppL antibody, RGD1562826 antibody, Sppl3-ps1 antibody, MGC52975 antibody, sppl3 antibody, MGC75937 antibody, fb94d08 antibody, wu:fb94d08 antibody, zgc:114093 antibody, 4833416I09Rik antibody, Psl4 antibody, Usmg3 antibody, IMP2 antibody, MDHV1887 antibody, PRO4332 antibody, PSH1 antibody, PSL4 antibody, Signal peptide peptidase-like antibody, signal peptide peptidase like 3 antibody, signal peptide peptidase like 3 L homeolog antibody, signal peptide peptidase 3 antibody, Intramembrane protease 2 antibody, SppL antibody, Sppl3 antibody, sppl3.L antibody, sppl3 antibody, SPPL3 antibody, imp-2 antibody
- 背景
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Background: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane protein substrates in or close to their luminal transmembrane domain boundaries (PubMed:16873890, PubMed:25354954, PubMed:25827571). Acts like a sheddase by mediating the proteolytic release and secretion of active site-containing ectodomains of glycan-modifiying glycosidase and glycosyltransferase enzymes such as MGAT5, B4GAT1 and B4GALT1 (PubMed:25354954, PubMed:25827571). Catalyzes the intramembrane cleavage of the envelope glycoprotein gp130 and/or the leader peptide gp18LP of the simian foamy virus independent of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852). May also have the ability to serve as a shedding protease for subsequent intramembrane proteolysis by SPPL2A and SPPL2B of the envelope glycoprotein gp130 (PubMed:23132852). Plays a role in the regulation of cellular glycosylation processes (PubMed:25354954). Required to link T-cell antigen receptor (TCR) and calcineurin-NFAT signaling cascades in lymphocytes by promoting the association of STIM1 and ORAI1 during store-operated calcium entry (SOCE) in a protease-independent manner (PubMed:25384971).
Aliases: SPPL3 antibody, IMP2 antibody, PSL4 antibody, Signal peptide peptidase-like 3 antibody, SPP-like 3 antibody, EC 3.4.23.- antibody, Intramembrane protease 2 antibody, IMP-2 antibody, Presenilin homologous protein 1 antibody, PSH1 antibody, Presenilin-like protein 4 antibody
- UniProt
- Q8TCT6
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