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SESN1 抗体 (AA 224-337) (HRP)

SESN1 适用: 人 ELISA 宿主: 兔 Polyclonal HRP
产品编号 ABIN7169408
发货至: 中国
  • 抗原 See all SESN1 抗体
    SESN1 (Sestrin 1 (SESN1))
    抗原表位
    • 16
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 224-337
    适用
    • 49
    • 31
    • 15
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    宿主
    • 47
    • 3
    克隆类型
    • 49
    • 1
    多克隆
    标记
    • 24
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SESN1 antibody is conjugated to HRP
    应用范围
    • 41
    • 16
    • 16
    • 13
    • 13
    • 7
    • 4
    • 3
    • 3
    • 2
    • 1
    ELISA
    交叉反应
    纯化方法
    >95%, Protein G purified
    免疫原
    Recombinant Human Sestrin-1 protein (224-337AA)
    亚型
    IgG
    Top Product
    Discover our top product SESN1 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原
    SESN1 (Sestrin 1 (SESN1))
    别名
    SESN1 (SESN1 产品)
    别名
    zgc:91970 antibody, sestrin-1 antibody, SESN1 antibody, XPA26 antibody, pa26 antibody, sest1 antibody, PA26 antibody, SEST1 antibody, 1110002G11Rik antibody, AU044290 antibody, Pa26 antibody, Sest1 antibody, sesn1-A antibody, sestrin 1 antibody, sestrin 1 L homeolog antibody, SESN1 antibody, sesn1 antibody, Sesn1 antibody, sesn1.L antibody
    背景

    Background: Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:25263562, PubMed:26449471). This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085). May have an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PubMed:15105503). However, this could not be confirmed (By similarity).

    Aliases: 1110002G11Rik antibody, AU044290 antibody, MGC118148 antibody, MGC138241 antibody, MGC142129 antibody, OTTMUSP00000022799 antibody, p53 activated gene 26 antibody, p53 regulated PA26 nuclear protein antibody, p53 regulated protein PA26 antibody, p53-regulated protein PA26 antibody, PA26 antibody, RP11-787I22.1 antibody, sesn1 antibody, SESN1_HUMAN antibody, SEST1 antibody, sestrin 1 antibody, Sestrin-1 antibody

    UniProt
    Q9Y6P5
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