-
- 抗原 See all WNK4 抗体
- WNK4 (WNK Lysine Deficient Protein Kinase 4 (WNK4))
-
抗原表位
- AA 828-1106
-
适用
- 人
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This WNK4 antibody is un-conjugated
- 应用范围
- ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- 交叉反应
- 人
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human Serine/threonine-protein kinase WNK4 protein (828-1106AA)
- 亚型
- IgG
-
anti-WNK Lysine Deficient Protein Kinase 4 (WNK4) (AA 1144-1243) antibody
WNK4 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 1E6 unconjugated
anti-WNK Lysine Deficient Protein Kinase 4 (WNK4) (AA 351-450) antibodyWNK4 适用: 小鼠 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-WNK Lysine Deficient Protein Kinase 4 (WNK4) antibodyWNK4 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
- Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 缓冲液
-
Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
- 抗原
- WNK4 (WNK Lysine Deficient Protein Kinase 4 (WNK4))
- 别名
- WNK4 (WNK4 产品)
- 别名
- WNK4 antibody, PHA2B antibody, PRKWNK4 antibody, 2010002J11Rik antibody, Pha2b antibody, Prkwnk4 antibody, Ac2-059 antibody, WNK lysine deficient protein kinase 4 antibody, WNK4 antibody, Wnk4 antibody
- 背景
-
Background: Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+) secretion to maintain integrated homeostasis. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition (By similarity).
Aliases: PHA 2B antibody, PHA2B antibody, PRKWNK 4 antibody, PRKWNK4 antibody, Protein kinase lysine deficient 4 antibody, Protein kinase lysine-deficient 4 antibody, Protein kinase with no lysine 4 antibody, Serine/threonine protein kinase WNK4 antibody, Serine/threonine-protein kinase WNK4 antibody, WNK lysine deficient protein kinase 4 antibody, Wnk4 antibody, WNK4_HUMAN antibody
- UniProt
- Q96J92
-
You are here:
