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VRK2 抗体 (AA 317-472) (Biotin)

VRK2 适用: 人 ELISA 宿主: 兔 Polyclonal Biotin
产品编号 ABIN7169219
发货至: 中国
  • 抗原 See all VRK2 抗体
    VRK2 (Vaccinia Related Kinase 2 (VRK2))
    抗原表位
    • 15
    • 8
    • 7
    • 6
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    AA 317-472
    适用
    • 33
    • 19
    • 1
    宿主
    • 45
    • 2
    • 1
    克隆类型
    • 47
    • 1
    多克隆
    标记
    • 16
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This VRK2 antibody is conjugated to Biotin
    应用范围
    • 39
    • 24
    • 13
    • 13
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    ELISA
    交叉反应
    纯化方法
    >95%, Protein G purified
    免疫原
    Recombinant Human Serine/threonine-protein kinase VRK2 protein (317-472AA)
    亚型
    IgG
    Top Product
    Discover our top product VRK2 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原
    VRK2 (Vaccinia Related Kinase 2 (VRK2))
    别名
    VRK2 (VRK2 产品)
    别名
    2810003O05Rik antibody, AI447698 antibody, vaccinia related kinase 2 antibody, VRK2 antibody, Vrk2 antibody
    背景

    Background: Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates \'Thr-18\' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Downregulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS. Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant.

    Aliases: 2810003O05Rik antibody, AI447698 antibody, EC 2.7.11.1 antibody, Serine/threonine protein kinase VRK2 antibody, Serine/threonine-protein kinase VRK2 antibody, Vaccinia related kinase 2 antibody, Vaccinia virus B1R related kinase 2 antibody, Vaccinia-related kinase 2 antibody, VRK 2 antibody, VRK2 antibody, VRK2_HUMAN antibody

    UniProt
    Q86Y07
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