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- 抗原 See all PLK3 抗体
- PLK3 (Polo-Like Kinase 3 (PLK3))
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抗原表位
- AA 487-646
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PLK3 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 交叉反应
- 人, 大鼠
- 纯化方法
- Antigen Affinity Purified
- 免疫原
- Recombinant Human Serine/threonine-protein kinase PLK3 protein (487-646AA)
- 亚型
- IgG
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anti-Polo-Like Kinase 3 (PLK3) (Internal Region) antibody
PLK3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Polo-Like Kinase 3 (PLK3) antibodyPLK3 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Polo-Like Kinase 3 (PLK3) (Internal Region) antibodyPLK3 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Polo-Like Kinase 3 (PLK3) (AA 1-646) antibodyPLK3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Polo-Like Kinase 3 (PLK3) (AA 1-646) antibodyPLK3 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Polo-Like Kinase 3 (PLK3) (AA 320-333) antibodyVerified PLK3 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Polo-Like Kinase 3 (PLK3) (AA 385-434) antibodyPLK3 适用: 人, 小鼠, 大鼠, 犬, 马, Pig, Cow, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Polo-Like Kinase 3 (PLK3) (AA 615-646), (C-Term) antibodyPLK3 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB0875 unconjugated
anti-Polo-Like Kinase 3 (PLK3) (Internal Region) antibodyPLK3 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- PLK3 (Polo-Like Kinase 3 (PLK3))
- 别名
- PLK3 (PLK3 产品)
- 别名
- cnk antibody, wu:fi35f10 antibody, fnk antibody, prk antibody, plx3 antibody, MGC89507 antibody, PLK2/3 antibody, NV15469 antibody, Plx3 antibody, CNK antibody, FNK antibody, PRK antibody, Cnk antibody, Fnk antibody, polo-like kinase 3 (Drosophila) antibody, polo like kinase 3 antibody, polo-like kinase 3 antibody, polo-like kinase 3 S homeolog antibody, polo-like kinase 3 L homeolog antibody, Serine/threonine-protein kinase plk-3 antibody, plk3 antibody, PLK3 antibody, LOC100118436 antibody, plk3.S antibody, plk3.L antibody, Plk3 antibody, plk-3 antibody
- 背景
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Background: Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia. Involved in DNA damage response and G1/S transition checkpoint by phosphorylating CDC25A, p53/TP53 and p73/TP73. Phosphorylates p53/TP53 in response to reactive oxygen species (ROS), thereby promoting p53/TP53-mediated apoptosis. Phosphorylates CHEK2 in response to DNA damage, promoting the G2/M transition checkpoint. Phosphorylates the transcription factor p73/TP73 in response to DNA damage, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates HIF1A and JUN is response to hypoxia. Phosphorylates ATF2 following hyperosmotic stress in corneal epithelium. Also involved in Golgi disassembly during the cell cycle: part of a MEK1/MAP2K1-dependent pathway that induces Golgi fragmentation during mitosis by mediating phosphorylation of VRK1. May participate in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation, via its interaction with CIB1.
Aliases: CNK antibody, Cytokine Inducible Kinase antibody, Cytokine-inducible serine/threonine-protein kinase antibody, FGF inducible kinase antibody, FGF-inducible kinase antibody, FNK antibody, PLK-3 antibody, Plk3 antibody, PLK3_HUMAN antibody, Polo Like Kinase 3 antibody, Polo-like kinase 3 antibody, PRK antibody, Proliferation Related Kinase antibody, Proliferation-related kinase antibody, Serine/threonine-protein kinase PLK3 antibody
- UniProt
- Q9H4B4
- 途径
- Regulation of long-term Neuronal Synaptic Plasticity
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