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PLK3 抗体 (AA 487-646)

PLK3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7169162
发货至: 中国
  • 抗原 See all PLK3 抗体
    PLK3 (Polo-Like Kinase 3 (PLK3))
    抗原表位
    • 8
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    AA 487-646
    适用
    • 45
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    • 2
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    宿主
    • 41
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    克隆类型
    • 45
    多克隆
    标记
    • 23
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    This PLK3 antibody is un-conjugated
    应用范围
    • 37
    • 28
    • 20
    • 4
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    交叉反应
    人, 大鼠
    纯化方法
    Antigen Affinity Purified
    免疫原
    Recombinant Human Serine/threonine-protein kinase PLK3 protein (487-646AA)
    亚型
    IgG
  • 应用备注
    Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原
    PLK3 (Polo-Like Kinase 3 (PLK3))
    别名
    PLK3 (PLK3 产品)
    别名
    cnk antibody, wu:fi35f10 antibody, fnk antibody, prk antibody, plx3 antibody, MGC89507 antibody, PLK2/3 antibody, NV15469 antibody, Plx3 antibody, CNK antibody, FNK antibody, PRK antibody, Cnk antibody, Fnk antibody, polo-like kinase 3 (Drosophila) antibody, polo like kinase 3 antibody, polo-like kinase 3 antibody, polo-like kinase 3 S homeolog antibody, polo-like kinase 3 L homeolog antibody, Serine/threonine-protein kinase plk-3 antibody, plk3 antibody, PLK3 antibody, LOC100118436 antibody, plk3.S antibody, plk3.L antibody, Plk3 antibody, plk-3 antibody
    背景

    Background: Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia. Involved in DNA damage response and G1/S transition checkpoint by phosphorylating CDC25A, p53/TP53 and p73/TP73. Phosphorylates p53/TP53 in response to reactive oxygen species (ROS), thereby promoting p53/TP53-mediated apoptosis. Phosphorylates CHEK2 in response to DNA damage, promoting the G2/M transition checkpoint. Phosphorylates the transcription factor p73/TP73 in response to DNA damage, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates HIF1A and JUN is response to hypoxia. Phosphorylates ATF2 following hyperosmotic stress in corneal epithelium. Also involved in Golgi disassembly during the cell cycle: part of a MEK1/MAP2K1-dependent pathway that induces Golgi fragmentation during mitosis by mediating phosphorylation of VRK1. May participate in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation, via its interaction with CIB1.

    Aliases: CNK antibody, Cytokine Inducible Kinase antibody, Cytokine-inducible serine/threonine-protein kinase antibody, FGF inducible kinase antibody, FGF-inducible kinase antibody, FNK antibody, PLK-3 antibody, Plk3 antibody, PLK3_HUMAN antibody, Polo Like Kinase 3 antibody, Polo-like kinase 3 antibody, PRK antibody, Proliferation Related Kinase antibody, Proliferation-related kinase antibody, Serine/threonine-protein kinase PLK3 antibody

    UniProt
    Q9H4B4
    途径
    Regulation of long-term Neuronal Synaptic Plasticity
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