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- 抗原 See all PTTG1 抗体
- PTTG1 (Pituitary Tumor-Transforming 1 (PTTG1))
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抗原表位
- AA 2-202
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PTTG1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 交叉反应
- 人
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human Securin protein (2-202AA)
- 亚型
- IgG
- Top Product
- Discover our top product PTTG1 Primary Antibody
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anti-Pituitary Tumor-Transforming 1 (PTTG1) (AA 2-199) antibody
PTTG1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Pituitary Tumor-Transforming 1 (PTTG1) (Internal Region) antibodyVerified PTTG1 适用: 人 ELISA, IHC, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Pituitary Tumor-Transforming 1 (PTTG1) (AA 1-202) antibodyPTTG1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Pituitary Tumor-Transforming 1 (PTTG1) (AA 1-202) antibodyPTTG1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Pituitary Tumor-Transforming 1 (PTTG1) (AA 2-202) antibodyPTTG1 适用: 人 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Pituitary Tumor-Transforming 1 (PTTG1) (AA 16-45), (N-Term) antibodyPTTG1 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB18596 unconjugated
anti-Pituitary Tumor-Transforming 1 (PTTG1) (AA 93-113) antibodyPTTG1 适用: 人 ELISA, IF 宿主: 小鼠 Monoclonal 1G10 unconjugated
anti-Pituitary Tumor-Transforming 1 (PTTG1) (AA 101-202) antibodyPTTG1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Pituitary Tumor-Transforming 1 (PTTG1) (AA 1-100) antibodyPTTG1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Pituitary Tumor-Transforming 1 (PTTG1) (AA 93-113) antibodyPTTG1 适用: 人 ELISA, IF 宿主: 小鼠 Monoclonal 3F9 unconjugated
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- 应用备注
- Recommended dilution: WB:1:500-1:5000,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- PTTG1 (Pituitary Tumor-Transforming 1 (PTTG1))
- 别名
- PTTG1 (PTTG1 产品)
- 别名
- EAP1 antibody, HPTTG antibody, PTTG antibody, TUTR1 antibody, PTTG1 antibody, securin antibody, AW555095 antibody, C87862 antibody, Pttg antibody, Pttg3 antibody, Securin antibody, Protein Cut2 antibody, pituitary tumor-transforming 1 antibody, pituitary tumor-transforming gene 1 antibody, securin, sister chromatid separation inhibitor antibody, PTTG1 antibody, Pttg1 antibody, cut2 antibody
- 背景
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Background: Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation.
Aliases: AW555095 antibody, C87862 antibody, Cut2 antibody, EAP 1 antibody, EAP1 antibody, ESP1 associated protein 1 antibody, Esp1-associated protein antibody, hPTTG antibody, MGC126883 antibody, MGC138276 antibody, Pds1 antibody, Pituitary tumor transforming 1 antibody, Pituitary tumor transforming protein 1 antibody, Pituitary tumor-transforming 1, isoform CRA_a antibody, Pituitary tumor-transforming 1, isoform CRA_b antibody, Pituitary tumor-transforming gene 1 antibody, Pituitary tumor-transforming gene 1 protein antibody, PTTG 1 antibody, PTTG antibody, PTTG1 antibody, PTTG1 protein antibody, PTTG1_HUMAN antibody, Pttg3 antibody, Securin antibody, Tumor transforming 1 antibody, Tumor transforming protein 1 antibody, Tumor-transforming protein 1 antibody, TUTR 1 antibody, TUTR1 antibody
- UniProt
- O95997
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