SKP2 抗体 (AA 1-424)
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- 抗原 See all SKP2 抗体
- SKP2 (S-Phase Kinase-Associated Protein 2 (SKP2))
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抗原表位
- AA 1-424
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SKP2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 交叉反应
- 人
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human S-phase kinase-associated protein 2 protein (1-424AA)
- 亚型
- IgG
- Top Product
- Discover our top product SKP2 Primary Antibody
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- 应用备注
- Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- SKP2 (S-Phase Kinase-Associated Protein 2 (SKP2))
- 别名
- SKP2 (SKP2 产品)
- 别名
- FBXL1 antibody, FBL1 antibody, FLB1 antibody, p45 antibody, RGD1562456 antibody, S-phase kinase-associated protein 2 (p45) antibody, S-phase kinase associated protein 2 antibody, Skp2 antibody, SKP2 antibody
- 背景
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Background: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration.
Aliases: CDK2/Cyclin A associated protein p45 antibody, Cyclin A/CDK2 associated protein p45 antibody, Cyclin-A/CDK2-associated protein p45 antibody, F box protein Skp2 antibody, F box/LRR repeat protein 1 antibody, F-box protein Skp2 antibody, F-box/LRR-repeat protein 1 antibody, FBL 1 antibody, FBL1 antibody, FBXL 1 antibody, FBXL1 antibody, FLB 1 antibody, FLB1 antibody, MGC1366 antibody, p45 antibody, p45skp2 antibody, S phase kinase associated protein 2 (p45) antibody, S phase kinase associated protein 2 antibody, S-phase kinase-associated protein 2 antibody, S-phase kinase-associated protein 2 E3 ubiquitin protein ligase antibody, SKP 2 antibody, Skp2 antibody, SKP2_HUMAN antibody
- UniProt
- Q13309
- 途径
- Mitotic G1-G1/S Phases
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