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RC3H2 抗体 (AA 251-506) (HRP)

RC3H2 适用: 人 ELISA 宿主: 兔 Polyclonal HRP
产品编号 ABIN7168435
发货至: 中国
  • 抗原 See all RC3H2 products
    RC3H2 (Membrane Associated DNA Binding Protein (RC3H2))
    抗原表位
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 251-506
    适用
    • 10
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    宿主
    • 9
    • 1
    克隆类型
    • 10
    多克隆
    标记
    • 7
    • 2
    • 1
    This RC3H2 antibody is conjugated to HRP
    应用范围
    • 4
    • 4
    • 2
    ELISA
    交叉反应
    纯化方法
    >95%, Protein G purified
    免疫原
    Recombinant Human Roquin-2 protein (251-506AA)
    亚型
    IgG
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原
    RC3H2 (Membrane Associated DNA Binding Protein (RC3H2))
    别名
    RC3H2 (RC3H2 产品)
    别名
    Mnab antibody, MNAB antibody, RNF164 antibody, 2900024N03Rik antibody, 9430019J22Rik antibody, D930043C02Rik antibody, Rnf164 antibody, ring finger and CCCH-type domains 2 antibody, ring finger and CCCH-type zinc finger domains 2 antibody, Rc3h2 antibody, RC3H2 antibody
    背景

    Background: Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3\'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation. May act as a ubiquitin E3 ligase. Involved in the ubiquitination of MAP3K5 (PubMed:24448648).

    Aliases: 2900024N03Rik antibody, 9430019J22Rik antibody, D930043C02Rik antibody, FLJ20301 antibody, FLJ20713 antibody, Membrane associated DNA binding protein antibody, Membrane associated nucleic acid binding protein antibody, Membrane-associated nucleic acid-binding protein antibody, MGC52176 antibody, MNAB antibody, OTTHUMP00000022076 antibody, OTTHUMP00000022077 antibody, OTTMUSP00000013545 antibody, OTTMUSP00000013546 antibody, Rc3h2 antibody, RC3H2_HUMAN antibody, Ring finger and CCCH type domains 2 antibody, RING finger and CCCH type zinc finger domain containing protein 2 antibody, Ring finger and CCCH-type zinc finger domain-containing protein 2 antibody, ring finger and CCCH-type zinc finger domains 2 antibody, RING finger protein 164 antibody, RNF164 antibody, roquin-2 antibody, RP23-321B3.1 antibody

    UniProt
    Q9HBD1
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