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RHOH 抗体 (AA 1-188)

RHOH 适用: 人 ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7168038
发货至: 中国
  • 抗原 See all RHOH 抗体
    RHOH (Ras Homolog Family Member H (RHOH))
    抗原表位
    • 13
    • 11
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 1-188
    适用
    • 40
    • 17
    • 15
    • 1
    宿主
    • 37
    • 3
    克隆类型
    • 38
    • 2
    多克隆
    标记
    • 19
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This RHOH antibody is un-conjugated
    应用范围
    • 26
    • 25
    • 10
    • 6
    • 4
    • 1
    • 1
    ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC)
    交叉反应
    纯化方法
    >95%, Protein G purified
    免疫原
    Recombinant Human Rho-related GTP-binding protein RhoH protein (1-188AA)
    亚型
    IgG
    Top Product
    Discover our top product RHOH Primary Antibody
  • 应用备注
    Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原
    RHOH (Ras Homolog Family Member H (RHOH))
    别名
    RHOH (RHOH 产品)
    别名
    ARHH antibody, TTF antibody, 5830400A04Rik antibody, AU019774 antibody, Arhh antibody, ras homolog family member H antibody, RHOH antibody, Rhoh antibody
    背景

    Background: Negative regulator of hematopoietic progenitor cell proliferation, survival and migration. Critical regulator of thymocyte development and T-cell antigen receptor (TCR) signaling by mediating recruitment and activation of ZAP70. Required for phosphorylation of CD3Z, membrane translocation of ZAP70 and subsequent activation of the ZAP70-mediated pathways. Essential for efficient beta-selection and positive selection by promoting the ZAP70-dependent phosphorylation of the LAT signalosome during pre-TCR and TCR signaling. Crucial for thymocyte maturation during DN3 to DN4 transition and during positive selection. Plays critical roles in mast cell function by facilitating phosphorylation of SYK in Fc epsilon RI-mediated signal transduction. Essential for the phosphorylation of LAT, LCP2, PLCG1 and PLCG2 and for Ca(2+) mobilization in mast cells. Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. Inhibits the activation of NF-kappa-B by TNF and IKKB and the activation of CRK/p38 by TNF. Inhibits activities of RAC1, RHOA and CDC42. Negatively regulates leukotriene production in neutrophils.

    Aliases: ARHH antibody, GTP binding protein TTF antibody, GTP-binding protein TTF antibody, OTTHUMP00000125213 antibody, Ras homolog gene family member H antibody, Rho related GTP binding protein antibody, Rho related GTP binding protein RhoH antibody, Rho-related GTP-binding protein RhoH antibody, RHOH antibody, RHOH_HUMAN antibody, Translocation three four protein antibody, TTF antibody, TTF translocation three four antibody

    UniProt
    Q15669
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