CoREST 抗体 (AA 394-482) (Biotin)
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- 抗原 See all CoREST (RCOR1) 抗体
- CoREST (RCOR1) (REST Corepressor 1 (RCOR1))
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抗原表位
- AA 394-482
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CoREST antibody is conjugated to Biotin
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应用范围
- ELISA
- 交叉反应
- 人
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human REST corepressor 1 protein (394-482AA)
- 亚型
- IgG
- Top Product
- Discover our top product RCOR1 Primary Antibody
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- CoREST (RCOR1) (REST Corepressor 1 (RCOR1))
- 别名
- RCOR1 (RCOR1 产品)
- 别名
- COREST antibody, RCOR antibody, 5730409O11 antibody, 6720480E22Rik antibody, AU042633 antibody, D12Wsu95e antibody, mKIAA0071 antibody, rcor1 antibody, xcoREST antibody, RCOR1 antibody, im:6904264 antibody, si:dkey-46n18.7 antibody, zgc:158607 antibody, RGD1305743 antibody, REST corepressor 1 antibody, REST corepressor 1 L homeolog antibody, RCOR1 antibody, Rcor1 antibody, rcor1.L antibody, rcor1 antibody
- 背景
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Background: Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation.
Aliases: COREST antibody, KIAA0071 antibody, Nr2b2 antibody, Nuclear receptor coregulator 1 antibody, Nuclear receptor subfamily 2 group B member 2 antibody, Protein CoREST antibody, RCOR antibody, Rcor1 antibody, RCOR1_HUMAN antibody, REST corepressor 1 antibody, Retinoic acid receptor RXR-beta antibody, Retinoid X receptor beta antibody, Rxrb antibody
- UniProt
- Q9UKL0
- 途径
- Regulation of Hormone Metabolic Process, Chromatin Binding
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