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RGMA 抗体 (AA 153-408) (HRP)

RGMA 适用: 人 ELISA 宿主: 兔 Polyclonal HRP
产品编号 ABIN7167712
发货至: 中国
  • 抗原 See all RGMA 抗体
    RGMA (RGM Domain Family, Member A (RGMA))
    抗原表位
    • 13
    • 7
    • 5
    • 1
    • 1
    • 1
    AA 153-408
    适用
    • 23
    • 4
    • 3
    • 1
    • 1
    宿主
    • 22
    • 1
    克隆类型
    • 21
    • 2
    多克隆
    标记
    • 10
    • 4
    • 3
    • 2
    • 2
    • 2
    This RGMA antibody is conjugated to HRP
    应用范围
    • 20
    • 19
    • 2
    • 1
    • 1
    • 1
    ELISA
    交叉反应
    纯化方法
    >95%, Protein G purified
    免疫原
    Recombinant Human Repulsive guidance molecule A protein (153-408AA)
    亚型
    IgG
    Top Product
    Discover our top product RGMA Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原
    RGMA (RGM Domain Family, Member A (RGMA))
    别名
    RGMA (RGMA 产品)
    别名
    RGM antibody, BC059072 antibody, C230063O06 antibody, repulsive guidance molecule family member a antibody, repulsive guidance molecule family member A antibody, RGMA antibody, Rgma antibody
    背景

    Background: Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.

    Aliases: Repulsive guidance molecule A antibody, RGM antibody, RGM domain family member A antibody, RGMA antibody, RGMA_HUMAN antibody

    UniProt
    Q96B86
    途径
    Tube Formation
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