HBXIP 抗体 (AA 1-91)
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- 抗原 See all HBXIP 抗体
- HBXIP (Hepatitis B Virus X-Interacting Protein (HBXIP))
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抗原表位
- AA 1-91
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This HBXIP antibody is un-conjugated
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应用范围
- ELISA, Immunohistochemistry (IHC)
- 交叉反应
- 人
- 纯化方法
- Antigen Affinity Purified
- 免疫原
- Recombinant Human Ragulator complex protein LAMTOR5 protein (1-91AA)
- 亚型
- IgG
- Top Product
- Discover our top product HBXIP Primary Antibody
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- 应用备注
- Recommended dilution: IHC:1:20-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- HBXIP (Hepatitis B Virus X-Interacting Protein (HBXIP))
- 别名
- LAMTOR5 (HBXIP 产品)
- 别名
- HBXIP antibody, xip antibody, XIP antibody, 1110003H18Rik antibody, Hbxip antibody, late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 antibody, Hepatitis B virus X-interacting protein antibody, LAMTOR5 antibody, xip antibody, Lamtor5 antibody
- 物质类
- Viral Protein
- 背景
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Background: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.
Aliases: HBV X interacting protein antibody, HBV X-interacting protein antibody, HBX interacting protein antibody, HBX-interacting protein antibody, hbxip antibody, HBXIP_HUMAN antibody, Hepatitis B virus X interacting protein antibody, Hepatitis B virus X-interacting protein antibody, LAMTOR5 antibody, Late endosomal/lysosomal adaptor MAPK and MTOR activator 5 antibody, MGC71071 antibody, Ragulator complex protein LAMTOR5 antibody, XIP antibody
- UniProt
- O43504
- 途径
- PI3K-Akt Signaling, Regulation of Cell Size
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