RSPO1 抗体 (AA 21-263)
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- 抗原 See all RSPO1 抗体
- RSPO1 (R-Spondin 1 (RSPO1))
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抗原表位
- AA 21-263
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This RSPO1 antibody is un-conjugated
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应用范围
- Immunohistochemistry (IHC), ELISA
- 交叉反应
- 人
- 纯化方法
- Antigen Affinity Purified
- 免疫原
- Recombinant Human R-spondin-1 protein (21-263AA)
- 亚型
- IgG
- Top Product
- Discover our top product RSPO1 Primary Antibody
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- 应用备注
- Recommended dilution: IHC:1:20-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- RSPO1 (R-Spondin 1 (RSPO1))
- 别名
- RSPO1 (RSPO1 产品)
- 别名
- RGD1565558 antibody, CRISTIN3 antibody, RSPO antibody, R-spondin antibody, Rspondin antibody, wu:fj81e05 antibody, zgc:92153 antibody, R-spondin 1 antibody, Rspo1 antibody, RSPO1 antibody, LOC100049655 antibody, rspo1 antibody
- 背景
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Background: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.
Aliases: CRISTIN3, FLJ40906, hRspo1, R spondin homolog, R spondin homolog (Xenopus laevis), R spondin1, R-spondin-1, Roof plate specific spondin, Roof plate-specific spondin-1, RP11-566C13.1, RSPO, Rspo1, RSPO1_HUMAN
- UniProt
- Q2MKA7
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