Ret Proto-Oncogene 抗体 (AA 29-300)
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- 抗原 See all Ret Proto-Oncogene (RET) 抗体
- Ret Proto-Oncogene (RET)
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抗原表位
- AA 29-300
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Ret Proto-Oncogene antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 交叉反应
- 人
- 纯化方法
- Antigen Affinity Purified
- 免疫原
- Recombinant Human Proto-oncogene tyrosine-protein kinase receptor Ret protein (29-300AA)
- 亚型
- IgG
- Top Product
- Discover our top product RET Primary Antibody
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- 应用备注
- Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- Ret Proto-Oncogene (RET)
- 别名
- RET (RET 产品)
- 别名
- c-ret antibody, cret antibody, etID315074.13 antibody, ret1 antibody, wu:fd13h01 antibody, X-ret antibody, ret-A antibody, xret antibody, RET antibody, MTC1 antibody, CDHF12 antibody, CDHR16 antibody, HSCR1 antibody, MEN2A antibody, MEN2B antibody, PTC antibody, RET-ELE1 antibody, RET51 antibody, RET9 antibody, c-Ret antibody, ret proto-oncogene receptor tyrosine kinase antibody, ret proto-oncogene S homeolog antibody, ret proto-oncogene antibody, ret antibody, ret.S antibody, RET antibody, Ret antibody
- 背景
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Background: Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis, involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer\\\'s patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a dependence receptor, in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several diseases such as neuroendocrine cancers, these diseases are characterized by aberrant integrins-regulated cell migration.
Aliases: C ret antibody, Cadherin family member 12 antibody, Cadherin related family member 16 antibody, CDHF 12 antibody, CDHF12 antibody, CDHR16 antibody, ELKS Fusion gene antibody, HSCR 1 antibody, HSCR1 antibody, Hydroxyaryl protein kinase antibody, MEN2A antibody, MEN2B antibody, MTC 1 antibody, MTC1 antibody, Multiple endocrine neoplasia and medullary thyroid carcinoma 1 antibody, Oncogene RET antibody, Proto oncogene tyrosine protein kinase receptor ret antibody, Proto-oncogene c-Ret antibody, Proto-oncogene tyrosine-protein kinase receptor ret antibody, PTC antibody, RET antibody, RET ELE1 antibody, Ret Proto oncogene antibody, RET transforming sequence antibody, RET_HUMAN antibody, RET51 antibody, RET9 antibody, tyrosine-protein kinase receptor ret antibody
- UniProt
- P07949
- 途径
- RTK signaling, Dopaminergic Neurogenesis, Regulation of Cell Size, Tube Formation
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