SAV1 抗体 (AA 1-210)
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- 抗原 See all SAV1 抗体
- SAV1 (Salvador Homolog 1 (SAV1))
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抗原表位
- AA 1-210
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SAV1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
- 交叉反应
- 人, 小鼠
- 纯化方法
- Antigen Affinity Purified
- 免疫原
- Recombinant Human Protein salvador homolog 1 protein (1-210AA)
- 亚型
- IgG
- Top Product
- Discover our top product SAV1 Primary Antibody
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anti-Salvador Homolog 1 (SAV1) (AA 300-383) antibody
SAV1 适用: 人 WB, ELISA, IF, IP 宿主: 小鼠 Monoclonal 3B2 unconjugated
anti-Salvador Homolog 1 (SAV1) (AA 1-210) antibodySAV1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Salvador Homolog 1 (SAV1) antibodySAV1 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Salvador Homolog 1 (SAV1) antibodySAV1 适用: 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Salvador Homolog 1 (SAV1) (AA 1-383) antibodySAV1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Salvador Homolog 1 (SAV1) (AA 300-383) antibodySAV1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Salvador Homolog 1 (SAV1) (AA 1-383) antibodySAV1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Salvador Homolog 1 (SAV1) (AA 65-92) antibodySAV1 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Salvador Homolog 1 (SAV1) (AA 266-315) antibodySAV1 适用: 人, 小鼠, 大鼠, Pig, 兔, 犬, 马, Bat, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200, IF:1:50-1:200, IP:1:200-1:2000,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- SAV1 (Salvador Homolog 1 (SAV1))
- 别名
- SAV1 (SAV1 产品)
- 别名
- SAV antibody, WW45 antibody, WWP4 antibody, 1700040G09Rik antibody, Salv antibody, Sav antibody, Wwp3 antibody, Wwp4 antibody, salvador family WW domain containing protein 1 antibody, salvador family WW domain containing 1 antibody, SAV1 antibody, Sav1 antibody
- 背景
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Background: Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation.
Aliases: 1700040G09Rik antibody, 45 kDa WW domain protein antibody, hWW 45 antibody, hWW45 antibody, Protein salvador homolog 1 antibody, salvador family WW domain containing protein 1 antibody, salvador homolog 1 (Drosophila) antibody, Salvador homolog 1 antibody, Salvador, Drosophila, homolog of antibody, SAV 1 antibody, SAV antibody, SAV1 antibody, SAV1_HUMAN antibody, WW 45 antibody, WW domain containing antibody, WW domain-containing adaptor 45 antibody, WW domain-containing protein, 45-KD antibody, WW45 antibody, WW45 protein antibody, WWP 4 antibody, WWP4 antibody
- UniProt
- Q9H4B6
- 途径
- Stem Cell Maintenance
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