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PKC beta 抗体 (AA 517-643)

PRKCB 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7165698
发货至: 中国
  • 抗原 See all PKC beta (PRKCB) 抗体
    PKC beta (PRKCB) (Protein Kinase C, beta (PRKCB))
    抗原表位
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    AA 517-643
    适用
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    宿主
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    克隆类型
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    多克隆
    标记
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    This PKC beta antibody is un-conjugated
    应用范围
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    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
    交叉反应
    人, 大鼠
    纯化方法
    >95%, Protein G purified
    免疫原
    Recombinant Human Protein kinase C beta type protein (517-643AA)
    亚型
    IgG
    Top Product
    Discover our top product PRKCB Primary Antibody
  • 应用备注
    Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原
    PKC beta (PRKCB) (Protein Kinase C, beta (PRKCB))
    别名
    PRKCB (PRKCB 产品)
    别名
    PKC-beta antibody, PKCB antibody, PRKCB1 antibody, PRKCB2 antibody, A130082F03Rik antibody, PKC-Beta antibody, Pkcb antibody, Prkcb1 antibody, Prkcb2 antibody, PKC-B antibody, Prkcb antibody, prkcb1 antibody, zgc:63591 antibody, PKC antibody, PRKCB_tv2 antibody, Pkc53E antibody, prkcb1l antibody, zgc:64063 antibody, protein kinase C beta antibody, protein kinase C, beta antibody, protein kinase C, beta b antibody, protein kinase C, beta a antibody, PRKCB antibody, Prkcb antibody, prkcbb antibody, prkcba antibody
    背景

    Background: Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at \\\'Ser-559\\\', \\\'Ser-644\\\' and \\\'Ser-652\\\'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at \\\'Ser-180\\\', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates \\\'Ser-36\\\' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of \\\'Thr-6\\\' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 \\\'Lys-4\\\' (H3K4me) by LSD1/KDM1A. In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. May participate in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription.

    Aliases: KPCB_HUMAN antibody, PKC Beta antibody, PKC-B antibody, PKC-beta antibody, PKCB antibody, Prkcb antibody, PRKCB II antibody, PRKCB2 antibody, Protein kinase C beta antibody, Protein kinase C beta type antibody

    UniProt
    P05771
    途径
    WNT signaling, TCR Signaling, Thyroid Hormone Synthesis, Nuclear Hormone Receptor Binding, Chromatin Binding, Myometrial Relaxation and Contraction, VEGF Signaling, Unfolded Protein Response, BCR Signaling
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