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JARID2 抗体 (AA 1-159) (Biotin)

JARID2 适用: 人 ELISA 宿主: 兔 Polyclonal Biotin
产品编号 ABIN7165673
发货至: 中国
  • 抗原 See all JARID2 抗体
    JARID2 (Jumonji, AT Rich Interactive Domain 2 (JARID2))
    抗原表位
    • 15
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-159
    适用
    • 40
    • 16
    • 9
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    宿主
    • 31
    • 9
    • 2
    • 1
    克隆类型
    • 34
    • 9
    多克隆
    标记
    • 19
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This JARID2 antibody is conjugated to Biotin
    应用范围
    • 29
    • 13
    • 13
    • 11
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    ELISA
    交叉反应
    纯化方法
    >95%, Protein G purified
    免疫原
    Recombinant Human Protein Jumonji protein (1-159AA)
    亚型
    IgG
    Top Product
    Discover our top product JARID2 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原
    JARID2 (Jumonji, AT Rich Interactive Domain 2 (JARID2))
    别名
    JARID2 (JARID2 产品)
    别名
    JMJ antibody, Jmj antibody, jumonji antibody, JARID2 antibody, jarid2 antibody, jmj antibody, si:dkey-211c3.1 antibody, Jumonji antibody, jarid2-a antibody, jarid2-b antibody, jarid2.S antibody, jarid2b antibody, jumonji and AT-rich interaction domain containing 2 antibody, jumonji, AT rich interactive domain 2 antibody, jumonji, AT rich interactive domain 2a antibody, jumonji, AT rich interactive domain 2b antibody, jumonji and AT-rich interaction domain containing 2 L homeolog antibody, JARID2 antibody, Jarid2 antibody, jarid2a antibody, jarid2 antibody, jarid2b antibody, jarid2.L antibody
    背景

    Background: Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of \\\'Lys-27\\\' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of \\\'Lys-9\\\' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling.

    Aliases: JARD2 antibody, JARD2_HUMAN antibody, JARID2 antibody, JMJ antibody, Jumonji AT rich interactive domain 2 antibody, Jumonji homolog antibody, Jumonji like protein antibody, Jumonji protein antibody, Jumonji/ARID domain containing protein 2 antibody, Jumonji/ARID domain-containing protein 2 antibody, Protein Jumonji antibody

    UniProt
    Q92833
    途径
    Chromatin Binding
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