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- 抗原 See all FAP 抗体
- FAP (Fibroblast Activation Protein, alpha (FAP))
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抗原表位
- AA 26-280
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This FAP antibody is un-conjugated
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应用范围
- ELISA, Immunohistochemistry (IHC)
- 交叉反应
- 人
- 纯化方法
- Antigen Affinity Purified
- 免疫原
- Recombinant Human Prolyl endopeptidase FAP protein (26-280AA)
- 亚型
- IgG
- Top Product
- Discover our top product FAP Primary Antibody
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anti-Fibroblast Activation Protein, alpha (FAP) (AA 525-624) antibody
FAP 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 1E5 unconjugated
anti-Fibroblast Activation Protein, alpha (FAP) (AA 26-264) antibodyFAP 适用: 人 ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 1H12F2 unconjugated
anti-Fibroblast Activation Protein, alpha (FAP) (AA 542-761) antibodyFAP 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Activation Protein, alpha (FAP) (AA 311-410) antibodyFAP 适用: 人, 小鼠, Cow WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Activation Protein, alpha (FAP) (AA 523-760) antibodyFAP 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Activation Protein, alpha (FAP) (AA 523-760) antibodyFAP 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal D1 unconjugated
anti-Fibroblast Activation Protein, alpha (FAP) (AA 542-761) antibodyFAP 适用: 小鼠 WB, IHC, IP, IF/ICC 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Activation Protein, alpha (FAP) (Internal Region) antibodyFAP 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IHC (p), ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Activation Protein, alpha (FAP) antibodyFAP 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Activation Protein, alpha (FAP) (AA 15-41), (N-Term) antibodyFAP 适用: 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB40867 unconjugated
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- 应用备注
- Recommended dilution: IHC:1:20-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- FAP (Fibroblast Activation Protein, alpha (FAP))
- 别名
- FAP (FAP 产品)
- 别名
- fap-A antibody, gene 13 antibody, FAP antibody, fapa antibody, dppiv antibody, seprase antibody, DPPIV antibody, FAPA antibody, fibroblast activation protein antibody, fibroblast activation protein alpha L homeolog antibody, fibroblast activation protein alpha antibody, fibroblast activation protein, alpha antibody, prolyl endopeptidase FAP antibody, Fap antibody, fap.L antibody, FAP antibody, fap antibody, LOC100547273 antibody
- 背景
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Background: Cell surface glycoprotein serine protease that participates in extracellular matrix degradation and involved in many cellular processes including tissue remodeling, fibrosis, wound healing, inflammation and tumor growth. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences, on substrate such as alpha-2-antiplasmin SERPINF2 and SPRY2 (PubMed:14751930, PubMed:16223769, PubMed:16480718, PubMed:16410248, PubMed:17381073, PubMed:18095711, PubMed:21288888, PubMed:24371721). Degrade also gelatin, heat-denatured type I collagen, but not native collagen type I and IV, vibronectin, tenascin, laminin, fibronectin, fibrin or casein (PubMed:9065413, PubMed:2172980, PubMed:7923219, PubMed:10347120, PubMed:10455171, PubMed:12376466, PubMed:16223769, PubMed:16651416, PubMed:18095711). Have also dipeptidyl peptidase activity, exhibiting the ability to hydrolyze the prolyl bond two residues from the N-terminus of synthetic dipeptide substrates provided that the penultimate residue is proline, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Pro and Pro-Pro (PubMed:10347120, PubMed:10593948, PubMed:16175601, PubMed:16223769, PubMed:16651416, PubMed:16410248, PubMed:17381073, PubMed:21314817, PubMed:24371721, PubMed:24717288). Natural neuropeptide hormones for dipeptidyl peptidase are the neuropeptide Y (NPY), peptide YY (PYY), substance P (TAC1) and brain natriuretic peptide 32 (NPPB) (PubMed:21314817). The plasma membrane form, in association with either DPP4, PLAUR or integrins, is involved in the pericellular proteolysis of the extracellular matrix (ECM), and hence promotes cell adhesion, migration and invasion through the ECM. Plays a role in tissue remodeling during development and wound healing. Participates in the cell invasiveness towards the ECM in malignant melanoma cancers. Enhances tumor growth progression by increasing angiogenesis, collagen fiber degradation and apoptosis and by reducing antitumor response of the immune system. Promotes glioma cell invasion through the brain parenchyma by degrading the proteoglycan brevican. Acts as a tumor suppressor in melanocytic cells through regulation of cell proliferation and survival in a serine protease activity-independent manner.
Aliases: 170 kDa melanoma membrane bound gelatinase antibody, 170 kDa melanoma membrane-bound gelatinase antibody, DPPIV antibody, FAP antibody, FAPA antibody, Fibroblast activation protein alpha antibody, Integral membrane serine protease antibody, SEPR_HUMAN antibody, Seprase antibody
- UniProt
- Q12884
- 途径
- Tube Formation
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