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- 抗原 See all KCNK1 抗体
- KCNK1 (Potassium Channel Subfamily K Member 1 (KCNK1))
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抗原表位
- AA 268-336
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This KCNK1 antibody is un-conjugated
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应用范围
- ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- 交叉反应
- 人
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human Potassium channel subfamily K member 1 protein (268-336AA)
- 亚型
- IgG
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anti-Potassium Channel Subfamily K Member 1 (KCNK1) (N-Term) antibody
KCNK1 适用: 人, 大鼠, 小鼠 ELISA, WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Potassium Channel Subfamily K Member 1 (KCNK1) (AA 53-69), (Extracellular), (P1 Loop) antibodyKCNK1 适用: 人, 大鼠, 小鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Potassium Channel Subfamily K Member 1 (KCNK1) (AA 265-336) antibodyKCNK1 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 4D7 unconjugated
anti-Potassium Channel Subfamily K Member 1 (KCNK1) (C-Term) antibodyKCNK1 适用: 人, 小鼠, 兔, 马, Pig, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Potassium Channel Subfamily K Member 1 (KCNK1) (AA 293-320), (C-Term) antibodyKCNK1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB32239 unconjugated
anti-Potassium Channel Subfamily K Member 1 (KCNK1) (AA 300-328), (C-Term) antibodyKCNK1 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- KCNK1 (Potassium Channel Subfamily K Member 1 (KCNK1))
- 别名
- KCNK1 (KCNK1 产品)
- 别名
- AI788889 antibody, TWIK-1 antibody, DPK antibody, HOHO antibody, K2P1 antibody, K2p1.1 antibody, KCNO1 antibody, TWIK1 antibody, Twik antibody, k2p1.1 antibody, twik-1 antibody, twik1 antibody, rabKCNK1 antibody, im:7150627 antibody, kcnk1 antibody, zgc:165664 antibody, potassium channel, subfamily K, member 1 antibody, potassium two pore domain channel subfamily K member 1 antibody, potassium channel, two pore domain subfamily K, member 1 L homeolog antibody, potassium channel, subfamily K, member 1a antibody, Kcnk1 antibody, KCNK1 antibody, kcnk1.L antibody, kcnk1a antibody
- 背景
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Background: Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues (PubMed:15820677, PubMed:21653227). Forms dimeric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel is selective for K(+) ions at physiological potassium concentrations and at neutral pH , but becomes permeable to Na(+) at subphysiological K(+) levels and upon acidification of the extracellular medium (PubMed:21653227, PubMed:22431633). The homodimer has very low potassium channel activity, when expressed in heterologous systems, and can function as weakly inward rectifying potassium channel (PubMed:8605869, PubMed:8978667, PubMed:15820677, PubMed:21653227, PubMed:22431633, PubMed:23169818, PubMed:25001086). Channel activity is modulated by activation of serotonin receptors (By similarity). Heterodimeric channels containing KCNK1 and KCNK2 have much higher activity, and may represent the predominant form in astrocytes (By similarity). Heterodimeric channels containing KCNK1 and KCNK3 or KCNK9 have much higher activity (PubMed:23169818). Heterodimeric channels formed by KCNK1 and KCNK9 may contribute to halothane-sensitive currents (PubMed:23169818). Mediates outward rectifying potassium currents in dentate gyrus granule cells and contributes to the regulation of their resting membrane potential (By similarity). Contributes to the regulation of action potential firing in dentate gyrus granule cells and down-regulates their intrinsic excitability (By similarity). In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (By similarity). Required for normal ion and water transport in the kidney (By similarity). Contributes to the regulation of the resting membrane potential of pancreatic beta cells (By similarity). The low channel activity of homodimeric KCNK1 may be due to sumoylation (PubMed:15820677, PubMed:20498050, PubMed:23169818). The low channel activity may be due to rapid internalization from the cell membrane and retention in recycling endosomes (PubMed:19959478).
Aliases: DPK antibody, HOHO antibody, HOHO1 antibody, inward rectifying potassium channel protein TWIK 1 antibody, Inward rectifying potassium channel protein TWIK-1 antibody, Inward rectifying potassium channel protein TWIK1 antibody, K2P1 antibody, K2p1.1 antibody, KCNK1 antibody, KCNK1_HUMAN antibody, KCNO1 antibody, OTTHUMP00000036029 antibody, Potassium channel KCNO1 antibody, Potassium channel subfamily K member 1 antibody, Potassium inwardly rectifying channel subfamily K member 1 antibody, TWIK 1 antibody, TWIK1 antibody
- UniProt
- O00180
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