CD36 抗体 (AA 191-376)

Background: Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on coreceptor signaling is strongly ligand specific. Cellular responses to these ligands are involved in angiogenesis, inflammatory response, fatty acid metabolism, taste and dietary fat processing in the intestine (Probable). Binds long-chain fatty acids and facilitates their transport into cells, thus participating in muscle lipid utilization, adipose energy storage, and gut fat absorption (By similarity) (PubMed:18353783, PubMed:21610069). In the small intestine, plays a role in proximal absorption of dietary fatty acid and cholesterol for optimal chylomicron formation, possibly through the activation of MAPK1/3 (ERK1/2) signaling pathway (By similarity) (PubMed:18753675). Involved in oral fat perception and preferences (PubMed:22240721, PubMed:25822988). Detection into the tongue of long-chain fatty acids leads to a rapid and sustained rise in flux and protein content of pancreatobiliary secretions (By similarity). In taste receptor cells, mediates the induction of an increase in intracellulare calcium levels by long-chain fatty acids, leading to the activation of the gustatory neurons in the nucleus of the solitary tract (By similarity). Important factor in both ventromedial hypothalamus neuronal sensing of long-chain fatty acid and the regulation of energy and glucose homeostasis (By similarity). Receptor for thombospondins, THBS1 and THBS2, mediating their antiangiogenic effects (By similarity). As a coreceptor for TLR4:TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, interacts with the heterodimer TLR4:TLR6, the complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion, through the priming and activation of the NLRP3 inflammasome (By similarity) (PubMed:20037584). Selective and nonredundant sensor of microbial diacylated lipopeptide that signal via TLR2:TLR6 heterodimer, this cluster triggers signaling from the cell surface, leading to the NF-kappa-B-dependent production of TNF, via MYD88 signaling pathway and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (By similarity) (PubMed:16880211).

Aliases: Adipocyte membrane protein antibody, BDPLT10 antibody, CD36 antibody, CD36 antigen (collagen type I receptor, thrombospondin receptor) antibody, CD36 antigen antibody, CD36 Molecule (thrombospondin receptor) antibody, CD36 Molecule antibody, CD36_HUMAN antibody, CHDS7 antibody, Cluster determinant 36 antibody, Collagen receptor, platelet antibody, FAT antibody, Fatty acid translocase antibody, Fatty acid transport protein antibody, Glycoprotein IIIb antibody, GP IIIb antibody, GP3B antibody, GP4 antibody, GPIIIB antibody, GPIV antibody, Leukocyte differentiation antigen CD36 antibody, MGC108510 antibody, MGC91634 antibody, PAS 4 protein antibody, PAS IV antibody, PAS-4 antibody, PASIV antibody, Platelet collagen receptor antibody, Platelet glycoprotein 4 antibody, Platelet glycoprotein IV antibody, scarb3 antibody, Scavenger receptor class B member 3 antibody, SR-B3 antibody, SRB3 antibody, Thrombospondin receptor antibody