PIWIL4 抗体 (AA 12-235)
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- 抗原 See all PIWIL4 抗体
- PIWIL4 (Piwi-Like 4 (PIWIL4))
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抗原表位
- AA 12-235
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PIWIL4 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunofluorescence (IF)
- 交叉反应
- 人
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human Piwi-like protein 4 protein (12-235AA)
- 亚型
- IgG
- Top Product
- Discover our top product PIWIL4 Primary Antibody
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- 应用备注
- Recommended dilution: WB:1:500-1:5000, IF:1:50-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- PIWIL4 (Piwi-Like 4 (PIWIL4))
- 别名
- PIWIL4 (PIWIL4 产品)
- 别名
- HIWI2 antibody, MIWI2 antibody, 9230101H05Rik antibody, Miwi2 antibody, piwi like RNA-mediated gene silencing 4 antibody, piwi-like RNA-mediated gene silencing 4 antibody, PIWIL4 antibody, Piwil4 antibody
- 背景
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Background: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Associates with secondary piRNAs antisense and PIWIL2/MILI is required for such association. The piRNA process acts upstream of known mediators of DNA methylation. Participates in a piRNA amplification loop. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity). May be involved in the chromatin-modifying pathway by inducing \\\'Lys-9\\\' methylation of histone H3 at some loci (PubMed:12906857).
Aliases: DKFZp686P01248 antibody, FLJ36156 antibody, HILI 2 antibody, HILI2 antibody, HIWI 2 antibody, HIWI2 antibody, Miwi 2 protein antibody, Miwi2 antibody, PIWI antibody, Piwi like 2 antibody, Piwi like 4 (Drosophila) antibody, Piwi like 4 antibody, Piwi like protein 4 antibody, PIWI like protein antibody, Piwi like RNA mediated gene silencing 4 antibody, Piwi-like protein 4 antibody, PIWIL 4 antibody, Piwil4 antibody, PIWL4_HUMAN antibody
- UniProt
- Q7Z3Z4
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