PIWIL1 抗体 (AA 390-690)
-
- 抗原 See all PIWIL1 抗体
- PIWIL1 (Piwi-Like 1 (PIWIL1))
-
抗原表位
- AA 390-690
-
适用
- 人
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This PIWIL1 antibody is un-conjugated
-
应用范围
- Immunohistochemistry (IHC), ELISA
- 交叉反应
- 人
- 纯化方法
- Antigen Affinity Purified
- 免疫原
- Recombinant Human Piwi-like protein 1 protein (390-690AA)
- 亚型
- IgG
- Top Product
- Discover our top product PIWIL1 Primary Antibody
-
-
- 应用备注
- Recommended dilution: IHC:1:20-1:200,
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
- 抗原
- PIWIL1 (Piwi-Like 1 (PIWIL1))
- 别名
- PIWIL1 (PIWIL1 产品)
- 别名
- ziwi antibody, PIWI antibody, HIWI antibody, MIWI antibody, piwi like RNA-mediated gene silencing 1 antibody, PIWI-like protein 1 antibody, putative PIWI-like protein 1 antibody, putative argonaut-like protein antibody, piwi-like RNA-mediated gene silencing 1 antibody, PIWIL1 antibody, Tb10.70.5520 antibody, LINJ_21_0470 antibody, LBRM_21_0470 antibody, piwil1 antibody, Piwil1 antibody
- 背景
-
Background: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Probable component of some RISC complex, which mediates RNA cleavage and translational silencing. Also plays a role in the formation of chromatoid bodies and is required for some miRNAs stability (By similarity). Isoform 3 may be a negative developmental regulator (PubMed:12037681, PubMed:16287078).
Aliases: HIWI antibody, MIWI antibody, Piwi (Drosophila) like 1 antibody, PIWI antibody, Piwi homolog antibody, Piwi like 1 (drosophila) antibody, Piwi like 1 antibody, Piwi-like protein 1 antibody, PIWIL1 antibody, PIWL1_HUMAN antibody
- UniProt
- Q96J94
-