PITX3 抗体 (AA 10-200) (Biotin)
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- 抗原 See all PITX3 抗体
- PITX3 (Pituitary Homeobox 3 (PITX3))
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抗原表位
- AA 10-200
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PITX3 antibody is conjugated to Biotin
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应用范围
- ELISA
- 交叉反应
- 人
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human Pituitary homeobox 3 protein (10-200AA)
- 亚型
- IgG
- Top Product
- Discover our top product PITX3 Primary Antibody
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- PITX3 (Pituitary Homeobox 3 (PITX3))
- 别名
- PITX3 (PITX3 产品)
- 别名
- CTPP4 antibody, CTRCT11 antibody, PTX3 antibody, pitx3 antibody, Ptx3 antibody, ak antibody, zgc:109716 antibody, pitx3-A antibody, xPitx3 antibody, paired like homeodomain 3 antibody, paired-like homeodomain 3 antibody, paired like homeodomain 3 L homeolog antibody, paired-like homeodomain transcription factor 3 antibody, paired-like homeodomain transcription factor Pitx3 antibody, PITX3 antibody, Pitx3 antibody, pitx3.L antibody, pitx3 antibody
- 背景
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Background: Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens epithelium, preventing activation of CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial cells in cell cycle (By similarity).
Aliases: Homeobox protein PITX 3 antibody, Homeobox protein PITX3 antibody, MGC12766 antibody, Paired like homeodomain transcription factor 3 antibody, Paired-like homeodomain transcription factor 3 antibody, Pituitary homeobox 3 antibody, PITX 3 antibody, Pitx3 antibody, PITX3_HUMAN antibody, PTX 3 antibody, PTX3 antibody
- UniProt
- O75364
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