NCOA1 抗体 (AA 284-393)
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- 抗原 See all NCOA1 抗体
- NCOA1 (Nuclear Receptor Coactivator 1 (NCOA1))
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抗原表位
- AA 284-393
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This NCOA1 antibody is un-conjugated
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应用范围
- ELISA, Immunohistochemistry (IHC)
- 交叉反应
- 人
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human Nuclear receptor coactivator 1 protein (284-393AA)
- 亚型
- IgG
- Top Product
- Discover our top product NCOA1 Primary Antibody
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- 应用备注
- Recommended dilution: IHC:1:20-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- NCOA1 (Nuclear Receptor Coactivator 1 (NCOA1))
- 别名
- NCOA1 (NCOA1 产品)
- 别名
- F-SRC-1 antibody, KAT13A antibody, RIP160 antibody, SRC1 antibody, bHLHe42 antibody, bHLHe74 antibody, si:dkey-5g7.6 antibody, si:dkey-34f16.6 antibody, NCOA1 antibody, SRC-1 antibody, nuclear receptor coactivator 1 antibody, NCOA1 antibody, ncoa1 antibody, Ncoa1 antibody
- 背景
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Background: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4, the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.
Aliases: bHLHe74 antibody, Class E basic helix-loop-helix protein 74 antibody, F SRC 1 antibody, Hin 2 protein antibody, Hin2 protein antibody, MGC129719 antibody, MGC129720 antibody, mNRC 1 antibody, NCoA 1 antibody, NCoA-1 antibody, Ncoa1 antibody, NCOA1_HUMAN antibody, Nuclear receptor coactivator 1 antibody, Nuclear receptor coactivator protein 1 antibody, NY REN 52 antigen antibody, Protein Hin 2 antibody, Protein Hin-2 antibody, Protein Hin2 antibody, Renal carcinoma antigen NY REN 52 antibody, Renal carcinoma antigen NY-REN-52 antibody, RIP 160 antibody, RIP160 antibody, SRC 1 antibody, SRC-1 antibody, Steroid receptor coactivator 1 antibody
- UniProt
- Q15788
- 途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha
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