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- 抗原 See all NUPR1 抗体
- NUPR1 (Nuclear Protein, Transcriptional Regulator, 1 (NUPR1))
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抗原表位
- AA 2-64
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This NUPR1 antibody is un-conjugated
- 应用范围
- ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- 交叉反应
- 人
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human Nuclear protein 1 protein (2-64AA)
- 亚型
- IgG
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anti-Nuclear Protein, Transcriptional Regulator, 1 (NUPR1) (C-Term) antibody
NUPR1 适用: 人, Cow, 犬, 马, 兔 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- NUPR1 (Nuclear Protein, Transcriptional Regulator, 1 (NUPR1))
- 别名
- NUPR1 (NUPR1 产品)
- 别名
- COM1 antibody, P8 antibody, 2310032H04Rik antibody, Com1 antibody, p8 antibody, nuclear protein 1, transcriptional regulator antibody, nuclear protein transcription regulator 1 antibody, NUPR1 antibody, Nupr1 antibody
- 背景
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Background: Chromatin-binding protein that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Interacts with MSL1 and inhibits its activity on histone H4 \'Lys-16\' acetylation (H4K16ac). Binds the RELB promoter and activates its transcription, leading to the transactivation of IER3. The NUPR1/RELB/IER3 survival pathway may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. In breast cancer cells, NUPR1 overexpression leads to the activation of PI3K/AKT signaling pathway, CDKN1A/p21 phosphorylation and relocalization from the nucleus to the cytoplasm, leading to resistance to chemotherapeutic agents, such as doxorubicin.
Aliases: Candidate of metastasis 1 antibody, COM1 antibody, Nuclear protein 1 antibody, Nupr1 antibody, NUPR1_HUMAN antibody, p8 protein antibody, Protein p8 antibody
- UniProt
- O60356
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