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- 抗原 See all Nischarin (NISCH) 抗体
- Nischarin (NISCH)
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抗原表位
- AA 500-700
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Nischarin antibody is un-conjugated
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应用范围
- ELISA, Immunohistochemistry (IHC)
- 交叉反应
- 人
- 纯化方法
- Antigen Affinity Purified
- 免疫原
- Recombinant Human Nischarin protein (500-700AA)
- 亚型
- IgG
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anti-Nischarin (NISCH) (AA 1246-1345) antibody
NISCH 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3B8 unconjugated
anti-Nischarin (NISCH) (AA 1246-1346) antibodyNISCH 适用: 人 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Nischarin (NISCH) (AA 1335-1435) antibodyNISCH 适用: 小鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Nischarin (NISCH) (AA 5-38) antibodyNISCH 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB55910 unconjugated
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- 应用备注
- Recommended dilution: IHC:1:20-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- Nischarin (NISCH)
- 别名
- NISCH (NISCH 产品)
- 别名
- NISCH antibody, IRAS antibody, 1200007D05Rik antibody, 3202002H23Rik antibody, AW494485 antibody, I-1 antibody, IR1 antibody, hIRAS antibody, nischarin antibody, nischarin S homeolog antibody, NISCH antibody, Cyan7822_6841 antibody, nisch.S antibody, nisch antibody, Nisch antibody
- 背景
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Background: Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension (By similarity). Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons (By similarity). Acts as a modulator of Rac-regulated signal transduction pathways (By similarity). Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity (By similarity). Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation (By similarity). Inhibits also LIMK1 kinase activity by reducing LIMK1 \\\'Tyr-508\\\' phosphorylation (By similarity). Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells (By similarity). Inhibits lamellipodia formation, when overexpressed (By similarity). Plays a role in protection against apoptosis. Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3. When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures.
Aliases: NISCH antibody, IRAS antibody, KIAA0975 antibody, Nischarin antibody, Imidazoline receptor 1 antibody, I-1 antibody, IR1 antibody, Imidazoline receptor antisera-selected protein antibody, hIRAS antibody, Imidazoline-1 receptor antibody, I1R antibody, Imidazoline-1 receptor candidate protein antibody, I-1 receptor candidate protein antibody, I1R candidate protein antibody
- UniProt
- Q9Y2I1
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