NOTCH2 抗体 (AA 59-250)
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- 抗原 See all NOTCH2 抗体
- NOTCH2 (Notch 2 (NOTCH2))
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抗原表位
- AA 59-250
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This NOTCH2 antibody is un-conjugated
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应用范围
- ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- 交叉反应
- 人
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human Neurogenic locus notch homolog protein 2 protein (59-250AA)
- 亚型
- IgG
- Top Product
- Discover our top product NOTCH2 Primary Antibody
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- 应用备注
- Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- NOTCH2 (Notch 2 (NOTCH2))
- 别名
- NOTCH2 (NOTCH2 产品)
- 背景
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Background: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Positively regulates self-renewal of liver cancer cells (PubMed:25985737).
Aliases: AGS2 antibody, hN2 antibody, Motch B antibody, N2 antibody, N2ECD antibody, N2ICD antibody, neurogenic locus notch homolog protein 2 antibody, NOTC2_HUMAN antibody, Notch 2 antibody, Notch 2 intracellular domain antibody, Notch Drosophila homolog 2 antibody, Notch homolog 2 antibody, Notch homolog 2 Drosophila antibody, Notch2 antibody
- UniProt
- Q04721
- 途径
- Notch Signaling, Stem Cell Maintenance
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