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SIRT7 抗体 (AA 242-379)

SIRT7 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7160866
发货至: 中国
  • 抗原 See all SIRT7 抗体
    SIRT7 (Sirtuin 7 (SIRT7))
    抗原表位
    • 16
    • 11
    • 8
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 242-379
    适用
    • 53
    • 37
    • 28
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    宿主
    • 68
    • 6
    • 2
    克隆类型
    • 72
    • 4
    多克隆
    标记
    • 35
    • 9
    • 6
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SIRT7 antibody is un-conjugated
    应用范围
    • 64
    • 30
    • 28
    • 16
    • 13
    • 13
    • 9
    • 7
    • 6
    • 4
    • 3
    • 3
    • 2
    • 1
    Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)
    交叉反应
    纯化方法
    >95%, Protein G purified
    免疫原
    Recombinant Human NAD-dependent protein deacetylase sirtuin-7 protein (242-379AA)
    亚型
    IgG
    Top Product
    Discover our top product SIRT7 Primary Antibody
  • 应用备注
    Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原
    SIRT7 (Sirtuin 7 (SIRT7))
    别名
    SIRT7 (SIRT7 产品)
    别名
    SIRT7 antibody, LOC796135 antibody, SIR2L7 antibody, sirtuin 7 antibody, phosphate cytidylyltransferase 2, ethanolamine antibody, SIRT7 antibody, sirt7 antibody, PCYT2 antibody, Sirt7 antibody
    背景

    Background: NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at \'Lys-18\' (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation.

    Aliases: NAD dependent deacetylase sirtuin 7 antibody, NAD dependent protein deacetylase sirtuin 7 antibody, NAD-dependent protein deacetylase sirtuin-7 antibody, Regulatory protein SIR2 homolog 7 antibody, Silent mating type information regulation 2 homolog antibody, Silent mating type information regulation 2 S.cerevisiae homolog 7 antibody, SIR2 L7 antibody, SIR2 like protein 7 antibody, Sir2 related protein type 7 antibody, SIR2, S.CEREVISIAE, HOMOLOG-LIKE 7 antibody, SIR2-like protein 7 antibody, SIR2L 7 antibody, SIR2L7 antibody, SIR7_HUMAN antibody, SIRT 7 antibody, SIRT7 antibody, Sirtuin 7 antibody, Sirtuin type 7 antibody, Sirtuin7 antibody

    UniProt
    Q9NRC8
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